Meatal stenosis: Difference between revisions

WikiAdmin (talk | contribs)
m replace <coauthors> parameter
mNo edit summary
 
(28 intermediate revisions by 2 users not shown)
Line 1: Line 1:
{{Construction Site}}
'''Meatal stenosis''' is a narrowing of the ''meatus'' (the opening of the [[urethra]]). Meatal stenosis is extremely rare in [[intact]] boys with a protective [[foreskin]]. About twenty percent of [[circumcised]] boys develop meatal stenosis. Meatal stenosis may be prevented by avoiding child [[circumcision]], which is a medically-unnecessary, non-therapeutic surgical [[amputation]] procedure.


== Background ==
== Background ==
Line 5: Line 5:
Genital disorders are commonly encountered in the office of the primary care physician.<ref>{{REFjournal
Genital disorders are commonly encountered in the office of the primary care physician.<ref>{{REFjournal
  |last=Joudi
  |last=Joudi
  |first=M.
  |init=M
  |last2=Fathi
  |last2=Fathi
  |first2=M.
  |init2=M
  |last3=Hiradfar
  |last3=Hiradfar
  |first3=M.
  |init3=M
  |title=Incidence of asymptomatic meatal stenosis in children following neonatal circumcision
  |title=Incidence of asymptomatic meatal stenosis in children following neonatal circumcision
  |journal=J Pediatr Urol
  |journal=J Pediatr Urol
Line 15: Line 15:
  |issue=5
  |issue=5
  |pages=526-528
  |pages=526-528
  |url=
  |url=https://www.sciencedirect.com/science/article/abs/pii/S1477513110004341
  |quote=
  |quote=
  |pubmedID=
  |pubmedID=20851685
  |pubmedCID=
  |pubmedCID=
  |DOI=
  |DOI=10.1016/j.jpurol.2010.08.005
  |date=Oct 2011
  |date=2011-10
  |accessdate=
  |accessdate=2020-02-01
}}</ref> Meatal stenosis is a relatively common acquired condition occurring in 9%-10% of males who are circumcised. This disorder is characterized by an upward deflected, difficult-to-aim urinary stream and, occasionally, dysuria and urgent, frequent, and prolonged urination. Surgical meatotomy is curative.
}}</ref> Meatal stenosis is a relatively common acquired condition occurring in 10%-20% of males who are [[Circumcision| circumcised]]. This disorder is characterized by an upward deflected, difficult-to-aim urinary stream and, occasionally, dysuria and urgent, frequent, and prolonged [[urination]]. Surgical meatotomy is curative.


== Pathophysiology ==
== Pathophysiology ==


After circumcision, a child who is not toilet-trained persistently exposes the meatus to urine, resulting in inflammation (ammoniacal dermatitis) and mechanical trauma as the meatus rubs against a wet diaper. This causes the loss of the delicate epithelial lining of the distal urethra. This loss may result in adherence of the epithelial lining at the ventral side, leaving a pinpoint orifice at the tip of the glans. Because this condition is exceedingly rare in uncircumcised children, circumcision is believed to be the most important causative factor of meatal stenosis.
After [[circumcision]] and the loss of [[Foreskin#Protective_functions| foreskin protection]], a child who is not toilet-trained persistently exposes the [[meatus]] to [[urine]], resulting in inflammation (ammoniacal dermatitis) and mechanical [[trauma]] as the meatus rubs against a wet diaper (nappie). This causes the loss of the delicate epithelial lining of the distal [[urethra]]. This loss may result in adherence of the epithelial lining at the ventral side, leaving a pinpoint orifice at the tip of the glans. Because this condition is exceedingly rare in [[intact]] children, [[circumcision]] is believed to be the most important causative factor of meatal stenosis.


Another hypothetical cause of this condition is ischemia due to damage to the frenular artery during circumcision, resulting in poor blood supply to the meatus and subsequent stenosis. In a prospective study of circumcised boys, Van Howe (2006) found meatal stenosis in 24 of 239 (7.29%) children older than 3 years, making meatal stenosis the most common complication of circumcision.<ref>{{REFjournal
Another hypothetical cause of this condition is ischemia due to damage to the frenular artery during [[circumcision]], resulting in poor blood supply to the meatus and subsequent stenosis. In a prospective study of circumcised boys, [[Robert S. Van Howe|Van Howe]] (2006) found meatal stenosis in 24 of 239 (7.29%) children older than 3 years, making meatal stenosis the most common complication of circumcision.<ref name="vanhowe2006">{{REFjournal
  |last=Van Howe
  |last=Van Howe
  |first=R.S.
  |init=RS
  |author-link=
  |author-link=Robert S. Van Howe
  |title=Incidence of meatal stenosis following neonatal circumcision in a primary care setting
  |title=Incidence of meatal stenosis following neonatal circumcision in a primary care setting
  |journal=Clin Pediatr (Phila)
  |journal=Clin Pediatr (Phila)
Line 37: Line 37:
  |issue=1
  |issue=1
  |pages=49-54
  |pages=49-54
  |url=
  |url=https://www.academia.edu/6992015/Incidence_of_Meatal_Stenosis_following_Neonatal_Circumcision_in_a_Primary_Care_Setting
  |quote=
  |quote=
  |pubmedID=
  |pubmedID=16429216
  |pubmedCID=
  |pubmedCID=https://doi.org/10.1177/000992280604500108
  |DOI=
  |DOI=
  |date=Jan-Feb 2006
  |date=2006-01
  |accessdate=
  |accessdate=2020-01-09
|note=Jan-Feb 2006
}}</ref>
}}</ref>


Line 52: Line 53:
==== International ====
==== International ====


Meatal stenosis affects 9%-10% of males who are circumcised.
Meatal stenosis affects 10%-20% of males who are [[circumcised]] in infancy.


=== Mortality/Morbidity ===
=== Mortality/Morbidity ===
Line 58: Line 59:
Meatal stenosis carries no risk of mortality.
Meatal stenosis carries no risk of mortality.


Morbidity is limited to the clinical symptoms and complications of surgical repair, including bleeding, infection, and recurrence.
Morbidity is limited to the clinical symptoms and complications of surgical repair, including [[bleeding]], [[infection]], and recurrence.


=== Race ===
=== Race ===


Meatal stenosis has no racial predilection. The condition can occur in circumcised males independent of ethnicity.
Meatal stenosis has no racial predilection. The condition can occur in [[circumcised]] males independent of ethnicity.


=== Sex ===
=== Gender ===


Meatal stenosis occurs only in males.
Meatal stenosis occurs only in males.
Line 70: Line 71:
=== Age ===
=== Age ===


Children who are not toilet-trained are more prone to develop meatal stenosis after circumcision because of exposure of the meatus to urine in diapers. Most children who are toilet-trained can verbalize their difficulties during micturition to their caregivers.
Children who are not toilet-trained are more prone to develop meatal stenosis after [[circumcision]] because of exposure of the meatus to ammonia from the [[urine]] in diapers. Most children who are toilet-trained can verbalize their difficulties during micturition to their caregivers.


== Clinical presentation ==
== Clinical presentation ==
Line 78: Line 79:
Patient history may include the following:
Patient history may include the following:


* Difficult-to-aim (upward deflected), high-velocity (long distance) stream of urine
* Difficult-to-aim (upward deflected), high-velocity (long distance) stream of [[urine]]
* Pain upon initiation of micturition
* Pain upon initiation of micturition
* Need to stand back from toilet or sit during urination
* Need to stand back from toilet or sit during urination
Line 91: Line 92:
Observation of the child while voiding helps immensely in confirming the diagnosis of the disorder.
Observation of the child while voiding helps immensely in confirming the diagnosis of the disorder.


If the physician desires to calibrate the meatus, Litvak et al report that the meatus in children younger than 1 year will accept a lubricated 5F feeding tube. They also report that, in children aged 1-6 years, an 8F feeding tube should pass without difficulty.<ref>{{REFjournal
If the physician desires to calibrate the meatus, Litvak et al. report that the meatus in children younger than 1 year will accept a lubricated 5F feeding tube. They also report that, in children aged 1-6 years, an 8F feeding tube should pass without difficulty.<ref>{{REFjournal
  |last=Litvak
  |last=Litvak
  |first=A.S.
  |init=AS
  |last2=Morris
  |last2=Morris
  |first2=J.A.
  |init2=JA
  |last3=McRoberts
  |last3=McRoberts
  |first3=J.W.
  |init3=JW
  |title=Normal size of the urethral meatus in boys
  |title=Normal size of the urethral meatus in boys
  |journal=J Urol
  |journal=J Urol
Line 105: Line 106:
  |url=
  |url=
  |quote=
  |quote=
  |pubmedID=
  |pubmedID=940216
  |pubmedCID=
  |pubmedCID=
  |DOI=
  |DOI=10.1016/s0022-5347(17)59355-6
  |date=Jun 1976
  |date=1976-06
  |accessdate=
  |accessdate=2020-02-01
}}</ref>
}}</ref>


=== Causes ===
=== Causes ===


In a child who is circumcised, persistent exposure of the meatus to urine and mechanical trauma from rubbing against a wet diaper results in ammoniacal dermatitis, loss of meatal epithelium, and fusion of its ventral edges. This results in a pinpoint orifice at the tip of the glans.
In a child who is [[circumcised]], persistent exposure of the [[meatus]] to [[urine]] and mechanical trauma from rubbing against a wet diaper results in ammoniacal dermatitis,<ref name="brenneman1921">{{REFjournal
|last=Brennemann
|init=J
|author-link=
|last2=
|init2=
|author2-link=
|url=http://www.cirp.org/library/complications/brennemann1/
|title=The ulcerated meatus in the circumcised child
|journal=Am J Dis Child
|date=1921
|volume=21
|issue=
|pages=38-47
|accessdate=2024-02-04
}}</ref> loss of meatal epithelium, and fusion of its ventral edges. This results in a pinpoint orifice at the tip of the [[glans]].


Other causes of meatal stenosis include the following:
Other causes of meatal stenosis include the following:
Line 123: Line 139:
* Balanitis xerotica obliterans
* Balanitis xerotica obliterans
** Balanitis xerotica obliterans (BXO), which is an unusual condition that causes a whitish discoloration and dry appearance of the glans, can also cause meatal stenosis.
** Balanitis xerotica obliterans (BXO), which is an unusual condition that causes a whitish discoloration and dry appearance of the glans, can also cause meatal stenosis.
** A 10-year retrospective series at Boston Children's Hospital included 41 patients with a median age of 10.6 years. Eighty-five percent of the patients were aged 8-13 years. The disease process was found to involve the prepuce, the glans, and, sometimes, the urethra. The most common referral diagnoses included phimosis (52%), balanitis (13%), and buried penis (10%). In 46% of the patients, circumcision was curative. Twenty-seven percent (11 patients) had meatal involvement that was treated by meatotomy and meatoplasty, and 22% required extensive plastic procedures of the penis, including buccal mucosal grafts.<ref>{{REFjournal
** A 10-year retrospective series at [http://www.childrenshospital.org/ Boston Children's Hospital] included 41 patients with a median age of 10.6 years. Eighty-five percent of the patients were aged 8-13 years. The disease process was found to involve the prepuce, the glans, and, sometimes, the [[urethra]]. The most common referral diagnoses included phimosis (52%), balanitis (13%), and buried penis (10%). In 46% of the patients, circumcision was curative. Twenty-seven percent (11 patients) had meatal involvement that was treated by meatotomy and meatoplasty, and 22% required extensive plastic procedures of the penis, including buccal mucosal grafts.<ref>{{REFjournal
  |last=Gargollo
  |last=Gargollo
  |first=P.C.
  |init=PC
  |last2=Kozakewich
  |last2=Kozakewich
  |first2=H.P.
  |init2=HP
  |last3=Bauer
  |last3=Bauer
  |first3=S.B.
  |init3=SB
  |etal=yes
  |etal=yes
  |title=Balanitis xerotica obliterans in boys
  |title=Balanitis xerotica obliterans in boys
Line 138: Line 154:
  |url=
  |url=
  |quote=
  |quote=
  |pubmedID=
  |pubmedID=16145451
  |pubmedCID=
  |pubmedCID=
  |DOI=
  |DOI=10.1097/01.ju.0000173126.63094.b3
  |date=Oct 2005
  |date=2005-10
  |accessdate=
  |accessdate=2020-01-01
}}</ref>
}}</ref>
** In children with BXO, meatal stenosis seems to be quite common.
** In children with BXO, meatal stenosis seems to be quite common.
Line 161: Line 177:
=== Surgical care ===
=== Surgical care ===


Serial dilatation results in small tears of the meatus, which are followed by secondary healing. In the long term, this creates a tighter stricture at the tip of the penis; therefore, this procedure is discouraged.
Serial dilatation results in small tears of the meatus, which are followed by secondary healing. In the long term, this creates a tighter stricture at the tip of the [[penis]]; therefore, this procedure is discouraged.


Meatotomy is the definitive treatment for meatal stenosis. Meatotomy is a simple procedure in which the ventrum of the meatus is crushed (for hemostasis) for 60 seconds with a straight mosquito hemostat and then divided with fine-tipped scissors.
Meatotomy is the definitive treatment for meatal stenosis. Meatotomy is a simple procedure in which the ventrum of the meatus is crushed (for hemostasis) for 60 seconds with a straight mosquito hemostat and then divided with fine-tipped scissors.


Brown et al reported excellent results following 130 office meatotomies with only 2 recurrences of meatal stenosis and 1 patient with bleeding requiring stitches. They also cited the cost-effectiveness of this treatment and noted good patient tolerance when a caring approach is used to reassure the child before and during the procedure. In this series, parents were encouraged to remain with the children during the operation, as their presence seemed to have a calming effect.<ref>{{REFjournal
Brown et al. (1997) reported excellent results following 130 office meatotomies with only 2 recurrences of meatal stenosis and 1 patient with [[bleeding]] requiring stitches. They also cited the cost-effectiveness of this treatment and noted good patient tolerance when a caring approach is used to reassure the child before and during the procedure. In this series, parents were encouraged to remain with the children during the operation, as their presence seemed to have a calming effect.<ref>{{REFjournal
  |last=Brown
  |last=Brown
  |first=M.R.
  |init=MR
  |last2=Cartwright
  |last2=Cartwright
  |first2=P.C.
  |init2=PC
  |last3=Snow
  |last3=Snow
  |first3=B.W.
  |init3=BW
  |title=Common office problems in pediatric urology and gynecology
  |title=Common office problems in pediatric urology and gynecology
  |journal=Pediatr Clin North Am
  |journal=Pediatr Clin North Am
Line 179: Line 195:
  |url=
  |url=
  |quote=
  |quote=
  |pubmedID=
  |pubmedID=9326954
  |pubmedCID=
  |pubmedCID=
  |DOI=
  |DOI=10.1016/s0031-3955(05)70549-6
  |date=Oct 1997
  |date=1997-10
  |accessdate=
  |accessdate=2020-02-01
}}</ref>
}}</ref>


* If the caregivers and the patient are cooperative, this procedure can be performed in the office of the physician using a topical eutectic mixture of local anesthetics (EMLA cream) applied liberally over the entire glans and secured in place for at least one hour with an occlusive dressing.
* If the caregivers and the patient are cooperative, this procedure can be performed in the office of the physician using a topical eutectic mixture of local anesthetics ([[EMLA]] cream) applied liberally over the entire glans and secured in place for at least one hour with an occlusive dressing.
* After being in place for one hour, the dressing is removed and the penis is prepared and draped into a sterile field.
* After being in place for one hour, the dressing is removed and the penis is prepared and draped into a sterile field.
* Throughout this procedure, reassure the child and tell him what is being done.
* Throughout this procedure, reassure the child and tell him what is being done.
Line 192: Line 208:
* Divide the crushed area with a straight fine-tipped scissor and apply an antibiotic ointment.
* Divide the crushed area with a straight fine-tipped scissor and apply an antibiotic ointment.
* After the operation, it is critical that the caregivers separate the edges of the meatus and apply antibiotic ointment or petroleum jelly twice a day for 2 weeks and then once a day for another 2 weeks to prevent one side of the meatotomy from adhering to the other side. Some medical professionals recommend dilation with a lubricated feeding tube or the tip of an ophthalmic ointment tube for a period of 4-8 weeks.
* After the operation, it is critical that the caregivers separate the edges of the meatus and apply antibiotic ointment or petroleum jelly twice a day for 2 weeks and then once a day for another 2 weeks to prevent one side of the meatotomy from adhering to the other side. Some medical professionals recommend dilation with a lubricated feeding tube or the tip of an ophthalmic ointment tube for a period of 4-8 weeks.
* In a survey of office pediatric urologic procedures, which included meatotomy, lysis of labial adhesions, and newborn circumcision, Smith and Smith (2000) found that 95 of 99 parents stated that they were satisfied with their decision to have these procedures performed in the office, and 95% reported good outcomes (only 1 patient had recurrent meatal stenosis).<ref>{{REFjournal
* In a survey of office pediatric urologic procedures, which included meatotomy, lysis of labial adhesions, and newborn circumcision, Smith & Smith (2000) found that 95 of 99 parents stated that they were satisfied with their decision to have these procedures performed in the office, and 95% reported good outcomes (only 1 patient had recurrent meatal stenosis).<ref>{{REFjournal
  |last=Smith
  |last=Smith
  |frist=C.
  |init=C
  |last2=Smith
  |last2=Smith
  |first2=D.P.
  |init2=DP
  |title=Office pediatric urologic procedures from a parental perspective
  |title=Office pediatric urologic procedures from a parental perspective
  |journal=Urology
  |journal=Urology
Line 204: Line 220:
  |url=
  |url=
  |quote=
  |quote=
  |pubmedID=
  |pubmedID=10688093
  |pubmedCID=
  |pubmedCID=
  |DOI=
  |DOI=10.1016/s0090-4295(99)00571-3
  |date=Feb 2000
  |date=2000-02
  |accessdate=
  |accessdate=2020-02-01
}}</ref>
}}</ref>
* Mild dysuria may be present for 1-2 days after meatotomy. If dysuria results in urinary retention, placing the child in a tub of warm water may stimulate micturition.
* Mild dysuria may be present for 1-2 days after meatotomy. If dysuria results in urinary retention, placing the child in a tub of warm water may stimulate micturition.
Line 230: Line 246:
=== Complications ===
=== Complications ===


Complications include bleeding during or after meatotomy, infection, and recurrence. All of these complications are quite rare and respond readily to appropriate management.
Complications include [[bleeding]] during or after meatotomy, infection, and recurrence. All of these complications are quite rare and respond readily to appropriate management.


Mild dysuria may persist for 1-2 days. Placing the child in a tub of warm water may provide relief.
Mild dysuria may persist for 1-2 days. Placing the child in a tub of warm water may provide relief.
Line 239: Line 255:


[[File:Kid_Friendly_Approach_to_Meatal_Stenosis.pdf]]
[[File:Kid_Friendly_Approach_to_Meatal_Stenosis.pdf]]
{{SEEALSO}}
* [[Meatus]]
{{REF}}
[[Category:Parental information]]


{{REF}}
[[Category:Penile disorder]]
[[Category:Penile illness]]
[[Category:Medicine]]
[[Category:Medical condition]]


[[Category:From Intactipedia]]
[[Category:From Intactipedia]]
[[Category:From IntactWiki]]
[[Category:From IntactWiki]]
[[Category:Penile disorders]]
[[Category:Medicine]]


[[de:Meatusstenose]]
[[de:Meatusstenose]]