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In his Materia medica, Dioscorides of Anazarbus (41–68 C.E.) suggested that the prepuce could be made supple to allow it to stretch by soaking it in honey and warm water repeatedly, provided the lipodermic condition not be due to circumcision.<ref>Dioscorides, ''De materia medica'' 2.82.2, in ''Pedanii Dioscuridis Anazarbei De materia medica'', ed. Max Wellmann, 3 vols. (Berlin: Weidmann, 1907), 1: 166.</ref> Dioscorides also recommended herbal treatment with the rubefacient plant thapsia (T. garganica). This plant was said to have the property of augmenting the volume of the parts onto it was applied, again, provided the condition was congenital and not the result of [[circumcision]].<ref>Ibid. 4.153.4–5 (Wellmann, 2: 300).</ref> Galen also advocated the use of thapsia and hinted that there were several topical preparations that were helpful for the treatment of lipodermic men.<ref>Galen, ''De compositione medicamentorum per genera'' 7.7 (Kühn, MG [n. 9], 13: 985).</ref>
=== [[Stretching ]] ===
In ancient Greece, athletes or komasts used preputial ligature to keep the prepuce covering the [[glans]] of the penis, as its exposure was seen as rude and vulgar (see [[kynodesme]]). The Ephesian physician Soranus, who lived under the reigns of Trajan and Hadrian (98–138 C.E.) indicates that there was a wider use of a ligature and a more general cultural diffusion of the concept of lipodermos. In his work ''Gynecology'', Soranus justifies the medically prescribed [[stretching ]] of the [[foreskin]] by an appeal to aesthetics. He advises wet nurses to massage the newborn child periodically, and to pay particular attention to performing manipulations designed to improve the appearance of the congenitally lipodermic penis:
''"If the male neonate appears to be lipodermic, [the wet nurse] should gently draw the [[Acroposthion| akroposthion]] forward or even hold it together with a strand of wool to fasten it. If gradually stretched and continuously drawn forward, it easily stretches and assumes its normal length, covers the glans penis and becomes accustomed to keep [a] natural good shape.''<ref>Soranus, ''Gynaeciorum'' 2.36.103.20–25, in ''Sorani Gynaeciorum libri IV'', ed. Johannes Ilberg (''CMG'', IV)(Leipzig: Teubner, 1927), p. 79; translation adapted from Owsei Temkin, trans., ''Soranus' Gynecology'' (Baltimore: Johns Hopkins Press, 1956), p. 107.</ref>
:''"When the [[skin]] of the penis needs only a short stretch in order to give it a natural appearance, I have often obtained the desired result through simple tension: I roll around the circumference of the penis a strip of strong and soft papyrus, after having coated the [[skin]] with glue. It is clear that it is necessary to glue the end of the strip of papyrus to the part of the same strip placed on the underside of the end. In effect, this device dries quickly and pulls without discomfort. One places under the [[skin]] of the posthe, on the interior fold, a rounded object of suitable dimension, that one can easily remove when the strip of papyrus is adhered. When I have no such object at my disposal, I often roll up and introduce a piece of papyrus of average size to serve as a support for the one with which I surround the penis. I want to be careful to provide the patient with a way to urinate easily when the paper rolled around his penis is completely solidified and the supporting one is removed. Some of those who use thapsia to return the posthe over the glans construct the round object in question in the form of little lead spout. They stretch the [[skin]] of the posthe over the exterior of this spout and secure it with a soft leather cord.This procedure can sometimes also be useful for those individuals who are missing a large amount of posthe. I also treat this surgically."''<ref>Oribasius, ''Collectionum medicarum reliquiae'' 50.1 (Raeder, ''OCMR'' [n. 36 ], 4: 55).</ref>
The alternative method that Galen outlines, that of inserting a lead spout under the prepuce and holding it in place by binding the enveloping prepuce with a leather cord would have added weight and perhaps tension, depending on the length of the lead spout, to the restorative technique.<ref name="hodges2001" /> Like the technique of Soranus, Galen's method of manually [[stretching ]] the deficient preputial [[skin]] over the glans and winding a leather cord around the "akroposthion" would have a similar effect to that of the [[kynodesme]]. These techniques depend for their efficacy on the principles of tissue expansion, today a major reconstructive technique. Given sufficient application of constant tension, new and permanent [[skin]] can be induced to grow. [[penile skin]], noted for its great elasticity, is especially responsive to expansion techniques.
=== Surgical treatment ===