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Various The conclusion of various studies come to show that the conclusion that EMLA-circumcisions effectiveness of young children are EMLA® is not suitable sufficient to sufficiently exclude the [[pain]] of non-therapeutic infant [[circumcision]].<ref name="lander1997" /> <ref>{{REFjournal
EMLA
,using template LanderJ etal 1997
|date=2005
|accessdate=2023-11-24
}}</ref> EMLA® was the least-effective of the three analgesia methods studied.<ref name="lander1997">{{REFjournal |last=Lander |init=J |first=Janice |author-link= |last2=Brady-Frerer |init2=B |first2=Barbara |author2-link= |last3=Metcalfe |init3=JB |first3=James B. |author3-link= |last4=Nazerali |init4=S |first4=Shermin |author4-link= |last5=Muttit |init5=S |first5=Sarah |author5-link= |LanderJ etal=no |title= Comparison of ring block, dorsal penile nerve block, and topical anesthesia for neonatal circumcision |journal=JAMA |location= |date=1997-12-24 |volume=278 |issue=24 |pages=2157-64 |url=http://www.cirp.org/library/pain/lander/ |archived= |quote= |pubmedID=9417009 |pubmedCID= |DOI= |accessdate=2023-12-01}}</ref>
Before the specification of the approval in 2013, EMLA® ointment was often used in the so-called ''off-label use''<ref>{{REFweb
}}</ref>
|title=Does topical Amethocaine cream increase first-Time successful cannulation in children compared with a eutectic mixture of local anaesthetics (EMLA) cream? A systematic review and meta-analysis of randomised controlled trials
|url=https://www.researchgate.net/publication/267728942
|DOI=10.1136/emermed-2014-204066
|accessdate=2020-12-19
}}</ref><ref>{{REFjournal
|url=https://pubmed.ncbi.nlm.nih.gov/30587535/
|title=Efficacy and Safety of EMLA Cream for Pain Control Due to Venipuncture in Infants: A Meta-analysis
|accessdate=2020-12-21
}}</ref>
{{SEEALSO}}
* [[Pain]]
{{REF}}
[[Category:Acronym]]