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|publisher=Nature America, Inc.
|accessdate=2011-08-30
}}</ref> It works by effecting ischemic [[necrosis]], forcing the foreskin tissue to die and fall off. This is marketed as an "advantage" over other circumcision devices and techniques, because it makes circumcision "bloodless, simple," and the manufacturing of easily-mass-produced parts allows for "scalable male circumcision programs in resource limited settings."<ref>{{REFweb
|last=
|first=
|publisher=PrePex
|accessdate=2011-08-30
}}</ref> In actuality, the concept of cutting off circulation to the [[foreskin ]] in order to effect ischemic [[necrosis ]] is found in other devices, such as the [[Circumplast]], [[Plastibell]], [[TARA KLamp]] and [[Sunathrone]] devices.
== Inventors ==
|publisher=The New York Times
|accessdate=2012-12-26
}}</ref> The [[Rakai Health Sciences Program]] is currently unveiling it and testing it in Uganda, presented by Godfrey Kigozi, program chief investigator, who stated that "it was invented in the [[United States of America]]. We have so far tested it on about 50 clients but we need 250 more to confirm its acceptability but so far it has worked properly with those who used it"<ref>{{REFweb
|last=
|first=
|accessdate=2011-08-30
}}</ref>.
==Video==
<br>
<youtube>v=ftYII-Ts5MM</youtube>
== Project abandoned in 2019 ==
Kenya officially adopted the device [...] in 2016 to expand safe circumcision methods. However, the uptake has been sluggish. The manufacturer says it has abandoned the project and is now offloading it to interested buyers. <q>Circ Medtech, the PrePex manufacturer, was unable to remove unreasonable [[WHO]]-imposed restrictions which have materially disadvantaged the product as compared to other circumcision methods for several years now", company CEO Eddy Horowitz said.<ref>{{REFweb
|url=https://www.the-star.co.ke/news/2019-07-04-bloodless-painless-circumcision-device-abandoned/
|title='Bloodless painless' circumcision device abandoned
The PrePex was withdrawn from the market in 2019.
==Circumcision does not prevent HIV infection==
=== Population-based studies ===
{{Population-based studies}}
===Two African surveys===
The previously reported studies were from developed Western nations. Now we have information from Sub_Saharan Africa.
French scientist [[Michel Garenne]], Ph.D. has published two reports in 2022 comparing the incidence of HIV infection in [[circumcised]] and [[intact]] men.
In his first report, Garenne presented the findings from a study in Lesotho, the enclave in South Africa. He reported:
<blockquote>
In couple studies, the effect of circumcision and VMMC on HIV was not significant, with similar transmission from female to male and male to female. The study questions the amount of effort and money spent on VMMC in Lesotho.<ref name="garenne2022A">{{REFjournal
|last=Garenne
|first=Michel
|init=M
|author-link=Michel Garenne
|title=Changing relationships between HIV prevalence and circumcision in Lesotho
|url=https://pubmed.ncbi.nlm.nih.gov/35373731/
|date=2022-04-04
|journal=J Biosoc Sci
|volume=online ahead of print
|pages=1-16
|DOI=10.1017/S0021932022000153
|pubmedID=35373731
|accessdate=2022-11-05
}}</ref>
</blockquote>
In his second report, Garenne (2022) presented information from six Sub-Saharan African nations (Eswatini, Lesotho, Malawi, Namibia, Zambia, Zimbabwe). He reported:
<blockquote>
"Results matched earlier observations made in South Africa that [[circumcised]] and [[intact]] men had similar levels of HIV infection."<ref name="garenne2022B">{{REFjournal
|last=Garenne
|first=Michael
|init=M
|author-link=
|etal=no
|title=Age-incidence and prevalence of HIV among intact and circumcised men: an analysis of PHIA surveys in Southern Africa
|trans-title=
|language=
|journal=J Biosoc Sci
|location=
|date=2022-10-26
|season=
|volume=
|issue=
|article=
|page=
|pages=1-13
|url=https://www.cambridge.org/core/journals/journal-of-biosocial-science/article/abs/ageincidence-and-prevalence-of-hiv-among-intact-and-circumcised-men-an-analysis-of-phia-surveys-in-southern-africa/CAA7E7BD5A9844F41C6B7CC3573B9E50
|archived=
|quote=
|pubmedID=36286328
|pubmedCID=
|DOI=10.1017/S0021932022000414
|accessdate=2022-11-05
}}</ref></blockquote>
{{SEEALSO}}
* [[Adolescent and adult circumcision]]
* [[Circumcision]]
* [[Adolescent and adult circumcisionIsrael]]
{{LINKS}}
* [http://PrePex.com/ PrePex™ website]
[[Category:Circumcision in Africa]]
[[Category:Circumcision productsproduct]]
[[Category:Financial gain]]
[[Category:Israel]]
[[Category:From CircLeaks]]