Changes

'''{{FULLPAGENAME}}''' is the term applied to the space on the [[foreskinned]] [[penis]] between the [[prepuce]] and the [[glans penis]].<ref>{{REFweb

}}</ref> The preputial sac may also be called the '''sub-preputial space''' or '''preputial cavity'''. [[Circumcised]] men do not have a preputial sac.

}}</ref> so it cannot be [[Infection| infected]]. The preputial sac will remain closed for a variable number of years. Thorvaldsen & Meyhoff (2005) conducted a survey of 4000 young men in [[Denmark]]. They reported that the mean age of first foreskin retraction is 10.4 years in [[Denmark]].<ref name="Thorvaldsen">{{REFjournal |last=Thorvaldsen |init=MA |last2=Meyhoff |init2=H |title=Patologisk eller fysiologisk fimose? |trans-title=Pathological or physiological phimosis? |language=Danish |journal=Ugeskr Læger |volume=167 |issue=17 |pages=1858-1862 |url=http://www.cirp.org/library/normal/thorvaldsen1/ |quote= |pubmedID= |pubmedCID= |DOI= |date=2005 |accessdate=2025-03-06}}</ref> Non-retractile foreskin is the more common condition until about 10-11 years of age.

The preputial sac is lined with [[mucosa]] as is appropriate for an internal organ where moisture is present.<ref name="cold-taylor1999">{{ColdCJ TaylorJR 1999}}</ref> [[Urine ]] and other sources of moisture are not harmful to it.

The [[glans penis]] (head of the [[penis]]) is covered and protected from friction , abrasion, [[trauma]], and abrasion [[infection]] by the [[foreskin]] while it is in the preputial sac, <ref name="fleiss1998">{{FleissP HodgesF VanHoweRS 1998}}</ref> so it does not accumulate [[keratin]], and maintains its [[Foreskin sensitivity| natural sensitivity]]. It is normal for the [[glans penis]] to be purple in color when the glans has been protected by the [[foreskin]].

Wetness A longer [[prepuce]] helps to keep out contaminants and pathogens.<ref name="fleiss1998" /> Lakshmanan & Parkash (1980) described the muscle fibers in the [[prepuce]] (known as the [[dartos]]), which contract to keep the prepuce snugly close to the [[glans penis]].<ref>{{REFjournal |last=Lakshmanan |first= |init=S |author-link= |last2=Parkash |first2= |init2=S |author2-link= |etal=no |title=Human prepuce: some aspects of structure and function |trans-title= |language= |journal=Indian J Surg |location= |date=1980 |volume=44 |issue= |article= |page= |pages=134-7 |url=http://www.cirp.org/library/anatomy/lakshmanan/ |archived= |quote= |pubmedID= |pubmedCID= |DOI= |accessdate=}}</ref> The muscle fibers form a whorl at the tip to keep the tip of the [[foreskin]] and keep the preputial sac closed against the outside world and contamination with pathogens.<ref name="fleiss1998" /> Cold & Taylor (1999) described a healthy [[microbiome]] that lives within the preputial sac.<ref name="cold-taylor1999" /> They also reported that Langerhans cells are found in the mucosa of the preputial sac . [[Langerhans cells]] are part of the immunological defenses of the [[penis]].  De Witte et al. (2007) reported that Langerhans cells produce a substance named ''langerin''. The langerin offers protection against HIV infection:{{Citation |Title=Langerin is a natural barrier to HIV-1 transmission by Langerhans cells |Text=Langerin prevents HIV-1 transmission by LCs. HIV-1 captured by Langerin was internalized into Birbeck granules and degraded. Langerin inhibited LC infection and this mechanism kept LCs refractory to HIV-1 transmission; inhibition of Langerin allowed LC infection and subsequent HIV-1 transmission. Notably, LCs also inhibited T-cell infection by viral clearance through Langerin. Thus Langerin is normal a natural barrier to HIV-1 infection, and associated strategies to combat infection must enhance, preserve or, at the very least, not interfere with having a Langerin expression and function. |Author= |Source= |ref=<ref>{{DeWitte etal 2007}}</ref>}}=== Sub-preputial moisture ===A longer [[foreskin| prepuce]]improves wetness in the preputial sac.<ref name="ofarrell2008">{{REFjournal

}}</ref> The preputial sac may also receive [[pre-ejaculate]]. The authors further reported that the wetness is rich in lytic material.<ref name="parkash1982" /> Lytic material causes lysis or a breakdown of pathogen cell walls.<ref>{{REFweb

}}</ref> Moistness also may be maintained by [[transudation]].<ref name="cold-taylor1999" /> The preputial sac may also receive [[pre-ejaculate]], which may be distinguished because it is more slippery. The sac may vary from very slightly moist to wetwhen one is aroused. === Foreskin fragrance ===The [[foreskin]] produces [[pheromone| pheromones]] that are likely to be present in the preputial sac.<ref name="fleiss1998" /> Many [[foreskinned]] men report a pleasant musky fragrance<ref name="vocabulary2024">{{REFweb |url=https://www.vocabulary.com/dictionary/musky |title=Musky |last= |first= |init= |publisher=vocabulary.com |date= |accessdate=2024-04-26}}</ref> from their [[penis]]. Musk is also produced by deer to create sexual arousal.<ref name="vocabulary2024" /> The fragrance, when it occurs, is emitted from the preputial sac.

A longer prepuce helps to keep out contaminants The fragrance may contain stimulating pheromones and pathogensis variously characterized. Lakshmanan & Parkash (1980) described the muscle fibers in the [[prepuce]] (known as the [[dartos]])A few find it offensive, but others find it attractive, pleasing, exciting, stimulating, which contract to keep the prepuce snugly close to the [[glans penis]]or arousing.<ref name="vocabulary2024" /> <ref>{{REFjournalREFweb |url=https://www.reddit.com/r/uncircumcised_talk/comments/1juhht2/scent/ |title=Scent |last=LakshmananAnonymous

|init=S

|last2publisher=ParkashReddit |first2date= |init2=S |author2-link= |etal=no |titleaccessdate=Human prepuce: some aspects of structure and function |trans2025-title= |language= |journal=Indian J Surg |location= |date=1980 |volume=44 |issue= |article= |page= |pages=13404-7 |url=http://www.cirp.org/library/anatomy/lakshmanan/09 |archived= |quote= |pubmedID= |pubmedCID= |DOI= |accessdate=}}</ref> The muscle fibers form a whorl at the tip to keep the tip of the [[foreskin]] and keep the preputial sac closed against the outside world and contamination.<ref name="fleiss1998">{{FleissP HodgesF VanHoweRS 1998}}</ref>

Cold & Taylor (1999) described a healthy [[microbiome]] Some believe that lives within the preputial sac.<ref name="cold-taylor1999" /> They also reported that Langerhans cells are found use of soap in the mucosa of the preputial sac. harms the natural [[Langerhans cellsmicrobiome]] are part of and increases the immunological defenses strength of the [[penis]].  De Witte et al. (2007) reported that Langerhans cells produce a substance named ''langerin''fragrance. The langerin offers protection against HIV infection:{{Citation |Title=Langerin is a natural barrier to HIV-1 transmission by Langerhans cells |Text=Langerin prevents HIV-1 transmission by LCs. HIV-1 captured musky foreskin fragrance may be contained by Langerin was internalized into Birbeck granules and degraded. Langerin inhibited LC infection and this mechanism kept LCs refractory to HIV-1 transmission; inhibition avoiding retraction of Langerin allowed LC infection and subsequent HIV-1 transmission. Notably, LCs also inhibited T-cell infection by viral clearance through Langerin. Thus Langerin is a natural barrier to HIV-1 infection, and strategies to combat infection must enhance, preserve or, at the very least, not interfere with Langerin expression and function. |Author= |Source= |ref=<ref>{{DeWitte etal 2007}}</ref>}} The [[foreskin]] produces [[pheromone| pheromones]] that are likely to be present in the preputial sac.<ref name="fleiss1998" />

Birley et al. (1993) studied 43 men with recurrent or persistent [[balanitis]] at an outpatient genitourinary disease clinic in London, [[United Kingdom| UK]] where most men are [[intact]]. Of the study group only 33 percent were [[circumcised]]. Birley and colleagues discovered that the men in that group washed frequently with soap.  The men were instructed to wash less frequently, to stop using soap, and to treat with emollients. The soap and shower gel apparently removed the natural skin oil, which appears to be essential for health of the [[mucosa]] of the preputial sac.<ref name="birley1993">{{REFjournal

== Urinationby foreskinned men==[[IntactForeskinned]] men sometimes ask, "do I have to retract my [[foreskin]] when I peefor [[urination]]?" <ref>Some men with abundant overhanging foreskin find it awkward and difficult to retract and keep retracted their [[foreskin]] because the foreskin is constantly pushing to glide forward to return to its normal position of covering and protecting the [[glans penis]].</ref> They may have been heard myths that it is unhealthy to have [[urine]] inside the [[foreskin]], however there is no factual basis for that claim. Urine is normally sterile has a healthy microbiome<ref name="cold-taylor1999" /> when it leaves the urethra and is helpful for flushing out the [[foreskin]] and keeping it clean. The presence of urine in the preputial sac is ''not'' unsanitary and does not do harm. Nature has planned for this condition. Boys by necessity pee through their [[foreskin]] because it the juvenile foreskin does not retract and men with [[phimosis]] also pee through their [[foreskin ]] because the foreskin does not retract. It does no harm so it is not necessary to pull back when you pee. The epithelium of all tissue in the preputial sac is [[Mucosa| mucosal membrane]] (similar to the inside of your mouth), which likes to be wet, so no damage or threat to health or well-being is caused by having [[urine]] inside the [[foreskin]]. The sphincter action of the preputial orifice functions as a one way valve, blocking the entry of contaminants and pathogens while allowing the passage of urine.<ref name="fleiss1998" /> The [[urine]] will serve to flush contaminants and pathogens out of the [[foreskin]]. A few individuals may experience [[ballooning of the foreskin]], which is harmless.

Everything in the preputial sac is covered with The [[foreskin]] overhang or [[Mucosa| mucosal membraneacroposthion]] (similar may be used as a hose nozzle to control and direct the inside of your mouth), which likes stream and may be adjusted as necessary to be wet, so no damage or threat achieve a smooth stream. It may help to health is caused by having urine inside the stretch one's [[foreskin]]out from one's body. The sphincter action of the preputial orifice functions as One man said, "When I need to pee, I open my fly, pull my foreskin out and give it a one way valvetug to get any wrinkles out, blocking then I hold my foreskin with the entry thumb and forefinger of contaminants both hands and pathogens while allowing use the passage overhang of urinemy foreskin as a nozzle to direct my stream.<ref name="fleiss1998" /> The urine will help When I finish, I milk it a bit to flush contaminants and pathogens get any residual pee out of the my [[foreskinpenis]]. Some individuals may experience [[ballooning of the foreskin]], which is harmless."

The [[foreskin]] overhang or [[acroposthionForeskinned]] men may be used enjoy feeling a slight tickling sensation as a hose nozzle to control and direct the stream. It may help to stretch one's [[foreskinurine]] flows out from one's body. One man said, "When I need to pee, I open my fly, pull my foreskin out and give it a tug to get any wrinkles out, then I hold my foreskin with the thumb and forefinger of both hands and use the overhang of my foreskin to direct my stream. When I finish, I milk it a bit to get any residual pee out of my through their [[urethraacroposthion]]."

One may retract or not retract for [[Foreskinnedurination]]. The human [[foreskin] men ] is highly flexible and stretchable. It may report feeling a slight tickling sensation be stretched as the urine flows out through their acroposthiondesired laterally and/or lengthwise to cause [[mitosis]] and [[tissue expansion]] to resolve issues.

One may pull back or not pull back when urinatingWhat works best depends to some extent on individual anatomy. Either way is okay.

A NSFW video image of a [[foreskinned]] man urinating through his [[acroposthion]].

https://www.reddit.com/r/4skinoverhang/comments/15xxkyc1jhcx5j/overhang_soft_peeemptying_the_hose/?chainedPosts=t3_15xxkyc

* {{REFweb

|accessdate=20232025-03-03}}* {{REFweb |url=https://intactamerica.org/intact-penis-care/ |title=Intact Penis Care: Embracing Natural Well-being |last=Garrett |first=Connor |init= |authorlink=Connor Justin Garrett |publisher=Intact America |date=2024-03-09 |accessdate=2024-05-10}}* {{REFweb |url=https://www.reddit.com/user/C4Charkey/comments/1jumg8s/the_accidental_intactivist_manifesto_iii_the/ |title=Section III. The Hygienic Hoax: Soap, Water, and the Ghosts of Victorian Anxiety |last=C4Charkey |first= |init= |author-link=C4Charkey |publisher=REDDIT |date=2025-04-08 |accessdate=2025-04-3112

[[Category:Medical termPhysiology]] [[de:Präputialsack]]