Changes

Thus, based on our results, it can be stated that the mechanosensory innervation of the human foreskin reaches its maximum value around the age of 20 (i.e., until [[puberty]]), remains stable during adulthood and decreases with maturity. The increase in CEOCs and MEOCs until adolescence might be related to the completion of maturation of the Meissner’s corpuscles or alternatively, it could be related to pubertal changes in the preputial skin. As for the reduction in older subjects, it cannot be certain whether this it is related to the cutaneous-mucosal microenvironment of the foreskin or to hormonal factors, although it is likely that it is both. In addition, it cannot be ruled out that it is a normal aging process of the peripheral somatosensory nervous system.<ref name="vega2025">{{REFjournal