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==Smegma was believed to be Carcinogenic==
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[[Image:Male smegma.jpg|right|thumb|Smegma on a human penis.]]
[[Image:Female smegma.jpg|right|thumb|Smegma on a human vulva.]]
Smegma is the name given to a flaky material that accumulates underneath the [[foreskin]] in males, and underneath the [[clitoral hood]] and within the labial folds in females. In males, it is composed of secretions of ectopic sebaceous glands in the foreskin, mixed with secretions of the prostate, seminal vesicles, mucin from the urethral glands, and desquamated epithelial cells.<ref>Parkash S, et al. Sub-Preputial Wetness - Its Nature. Ann Nat Med Sci (India) 1982;18(3):109-112.</ref><ref>Hyman AB; Brownstein MH. Tyson's "Glands," Archives of Dermatology, vol. 99, no. 1 (January 1969): pp. 31-37.</ref><ref>Van Howe RS, Hodges FM. The carcinogenicity of smegma: debunking a myth. J Eur Acad Dermatol Venereol 2006;20(9):1046.</ref>
== Smegma is the name given was believed to a flaky material that accumulates underneath the [[foreskin]] in males, and underneath the [[clitoral hood]] and within the labial folds in females. In males, it is composed of secretions of ectopic sebaceous glands in the foreskin, mixed with secretions of the prostate, seminal vesicles, mucin from the urethral glands, and desquamated epithelial cells.<ref>Parkash S, et al. Sub-Preputial Wetness - Its Nature. Ann Nat Med Sci (India) 1982;18(3):109-112.</ref><ref>Hyman AB; Brownstein MH. Tyson's "Glands," Archives of Dermatology, vol. 99, no. 1 (January 1969): pp. 31-37.</ref><ref>Van Howe RS, Hodges FM. The carcinogenicity of smegma: debunking a myth. J Eur Acad Dermatol Venereol 2006;20(9):1046.</ref> be carcinogenic ==
Circumcision advocates of the past who alleged a relationship between "lack of circumcision" and genital cancers formerly implicated smegma or smegma-borne pathogens as the causative agent. Only two histologic studies of human smegma have ever been conducted, both of which found it to be perfectly harmless.