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Weiss joined the United States Army as an aviation medical officer in 1945. Later he practiced medicine for about 25 years as a general surgeon in Lake Charles, Louisiana. Later he joined the [https://www.airforce.com/ United States Air Force] as a Flight Surgeon with the rank of Lieutenant Colonel.
As with many other [[circumcised doctors]], Weiss was an advocate of child [[circumcision]]. Weiss et al. (1993) proposed speculated that the [[Langerhans cells]] in the [[prepuce]] may serve as a portal -of -entry for [[HIV]] infection.<ref name="weiss1993">{{REFjournal
|last=Weiss
|first=Gerald N.