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|Text=At Cell Applications, Inc., primary Human Dermal Fibroblasts are isolated from the dermis of normal human neonatal [[foreskin]] or adult [[skin]]*. They are cryopreserved at the end of primary culture and can be cultured and propagated for at least 16 population doublings. The cells are tested positive for fibroblast surface protein, and can be shipped frozen or proliferating, with all the media reagents included. HDF provide a well-established system for in vitro analysis of fibroblast growth, migration and collagen metabolism. Fibroblasts grown in a biodegradable mesh have been used as a living dermal replacement.