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Taddio & colleagues (1995)(1997) studied the effect of neonatal [[circumcision]] on the behavior of boys after surgery and at the time of vaccination. It was found that [[circumcised]] boys had a higher pain response at time of vaccination six months later as compared with [[intact]] boys,<ref name="taddio"1995">{{Taddio TaddioA etal 1995}}</ref><ref name="taddio1997">{{Taddio Katz Ilersich Koren 1997}}</ref> showing that the nervous system had been permanently sensitized to heightened pain sensation.