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Although a [[circumcision]] may be performed at any age, circumcisions are most commonly performed on newborn boys in the first month of life outside of the mother's womb. At that tender age general anesthesia is too dangerous to administer, so newborn boys receive only minimal [[pain]] relief at best and, in many cases, none at all.
[[circumcised]] boys had a higher pain response at time of vaccination six months later as compared with [[intact]] boys,<ref name="taddio"1995">{{TaddioA etal 1995}}</ref><ref name="taddio1997">{{Taddio Katz Ilersich Koren TaddioA KatzJ IlersichAL KorenG 1997}}</ref> showing that the nervous system had been permanently sensitized to heightened pain sensation.
Taddio et al. (1997) concluded: