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Nqeketo, through the Ikamva Lesizwe Institute, appears to be working actively to promote medical circumcision and to make traditional circumcision safer. He appears to have taken a strong position in favor of male circumcision, however one paper reported that "[c]ircumcision had no protective effect in the prevention of HIV transmission."<ref>{{REFjournal
|last=Connolly
|first=C.
|author-link=
|last2=Simbayi
|first2=LCL.C.
|author2-link=
|last3=Shanmugam
|first3=R.
|author3-link=
|last4=Nqeketo
|first4=A. |author4-link=Ayanda Nqeketo
|etal=no
|title=Male circumcision and its relationship to HIV infection in South Africa: results of a national survey in 2002
|journal=S Afr Med J
|date=2008-10
|volume=98
|pages=789-94
|url=
|pubmedID=19115756
|pubmedCID=
|accessdate=2020-04-03
}}</ref>