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A classic 1993 study on HPV came up with the following conclusions: "Uncircumcised men had a lower prevalence of genital warts than circumcised men... The presence of the foreskin may confer non specific protection of the proximal penis from acquisition of HPV infection."
<ref>{{REFjournal
| last=Cook | first=LSL.S. | coauthorslast2=Koutsky LA, |first2=L.A. |last3=Holmes KK, |first4=K.K. | title=Clinical presentation of genital warts among circumcised and uncircumcised heterosexual men attending an urban STD clinic | journal=Genitourin Med | volume=69 | issue=4 | pages=262-4 | url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1195083/ | quote= | pubmedID= | pubmedCID=1195083 | DOI= | date=1993 Aug | accessdate=
}}</ref>
A meta-analysis performed by Dr. [[Robert Van Howe]] in 2006 found no significant association between circumcision status and HPV infection. "The medical literature does not support the claim that circumcision reduces the risk for genital HPV infection"<ref>{{REFjournal
| last=Van Howe | first=Robert S. | coauthorsauthor-link=Robert Van Howe | title=Human papillomavirus and circumcision: A meta-analysis | journal=Journal of Infection | volume=54 | issue=5 | pages=490-496 | url=http://www.cirp.org/library/disease/cancer/vanhowe2006b/ | quote= | pubmedID= | pubmedCID= | DOI= | date=May 2007 | accessdate=2008-09-18
}}</ref>.
"The percentage of circumcised men reporting a diagnosis of genital warts was significantly higher than uncircumcised men, 4.5% (95% CI, 3.6%–5.6%) versus 2.4% (95% CI, 1.5%–4.0%)".
<ref>{{REFjournal
| last=Dinh | first=T.H. | coauthorsfirst2=M. |last2=Sternberg, |first3=E.F. |last3=Dunne and |first4=L.E. |last4=Markowitz | title=Genital Warts Among 18- to 59-Year-Olds in the United States, National Health and Nutrition Examination Survey, 1999–2004 | journal=Sexually Transmitted Diseases | volume=35 | issue=4 | pages=357-360 | url=http://journals.lww.com/stdjournal/Fulltext/2008/04000/Seroepidemiology_of_Human_Papillomavirus_Type_11.8.aspx | quote= | pubmedID= | pubmedCID= | DOI= | date=April 2008 | accessdate=2011-03-05
}}</ref>
A 2011 study on University of Washington students found no correlation between circumcision and HPV.<ref>{{REFjournal
| last=VanBuskirk | first=Kelley PhD | coauthorslast2=Winer, |first2=Rachel L. PhD; |last3=Hughes, |first3=James P. PhD; |last4=Feng, |first4=Qinghua PhD; |last5=Arima, |first5=Yuzo PhD; |last6=Lee, |first6=Shu-Kuang MS; |last7=Stern, |first7=Michael E. MN, ARNP; |last8=O'Reilly, |first8=Sandra F. BS; |last9=Koutsky, |first9=Laura A. PhD | title=Circumcision and Acquisition of Human Papillomavirus Infection in Young Men | journal=Sexually Transmitted Diseases | volume=38 | issue=12 | pages= | url= | quote=rates of acquiring clinically relevant HPV types... did not differ significantly by circumcision status | pubmedID= | pubmedCID= | DOI=10.1097/OLQ.0b013e31822e60cb | date=December 2011 | accessdate=2011-09-02
}}</ref> This study tested for HPV at three sites: the scrotum/shaft skin, the glans, and in urine samples. The authors of this study found that in circumcised men, the scrotum/shaft skin contained was most often the site of HPV infection. The authors also note that many large-scale studies fail to test for HPV on scrotum/shaft skin.