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Immunological and protective function of the foreskin

4 bytes added, 16:40, 19 January 2022
m
wikify Urinary meatus
<!--In infancy, simple sugars in breast milk, like antibacterial oligosaccharides, are acquired from the mother's milk and excreted in [[urine]]. University studies have shown that these substances cling to the [[mucosa]]l lining of the inner foreskin and protect against urinary tract infections,<ref>Hanson LA, Karlsson B, Jalil F, ''et al''. Antiviral and antibacterial factors in human milk. In: Hanson LA, ed. ''Biology of Human Milk''. New York Raven Press; 1988. pp. 141-57</ref> as well as infections in other parts of the body.<ref>Coppa GV, Gabrielli O, Giorgi P, Catassi C, Montanari MP, Veraldo PE, Nichols BL. Preliminary study of breast feeding and bacterial adhesion to uroepithelial cells. ''Lancet'' 1990 Mar 10;335(8689):569-71.</ref> Babies excrete in their [[urine]] about 300-500 milligrams of oligosaccharides each day. These compounds prevent virulent strains of ''Escherichia coli'' from adhering to the [[mucosa]]l lining of the entire urinary tract, including the foreskin and glans. For these reasons breast-milk is highly efficacious at preventing UTI.<ref>Gothefors L, Olling S, Winberg J. Breastfeeding and biological properties of faecal ''E. coli'' strains. ''Acta Paediatr Scand'' 1975 Nov;54(6):807-12.</ref> Rigorous studies have repeatedly demonstrated that breast feeding protects against urinary tract infections.<ref>Mårild S. Breastfeeding and Urinary Tract Infections. ''Lancet'' 1990;336:942.</ref> <ref>Pisacane A, ''et al''. Breastfeeding and urinary tract infection. ''The Lancet'', July 7, 1990, p50 </ref> <ref>Pisacane A, Graziano L, Mazzarella G, ''et al''. Breast-feeding and urinary tract infection. ''J Pediatr'' 1992;120:87-89.</ref>
Researchers have shown that premature foreskin retraction can expose the penis to hospital strains of ''Escherichia coli'' and can result in UTI.<ref>Winberg J ''et al''. The prepuce: A mistake of nature? ''Lancet'' 1989, pp.598-99.</ref> Hence the protective function of the foreskin is in the child's best interest, especially during chemically treated diaper wearing years where feces mixed with [[urine]] can not only contaminate the permanently exposed [[urinary meatus ]] but also the [[amputation]] wound from the circumcision surgery itself.
It is important to note that women have a higher risk of UTI. This is because the shorter [[urethra]] offers less protection via the immunological function of the [[urethra]]'s [[mucosa]]l lining. By the same observation we see that the tubular tip of the foreskin and its [[mucosa]]l lining act as an extension of the [[urethra]], hence providing more of that same protection via [[mucosa]] immunology and the adherence of antibacterial substances in breast milk. Understandably, removal of the foreskin destroys all this functionality.-->
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