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Add link in SEALSO section.
|accessdate=2019-10-20
}}</ref> which is a very important non-antibody protein that generates immune response when in contact with specific agents. Plasma cells which increase in number in response to pathogens levels, secrete immunoglobulin.<ref name="flower1983"/>
It is also very important to note that [[Langerhans cells]] that are present in the [[foreskin]] produce ''Langerin'', a substance that has been proven to kill human immunodeficency immunodeficiency virus ([[HIV]]) on contact.<ref>{{DeWitte etal 2007}}</ref>
All of these function to sequester and “digest” foreign pathogens. All these substances play an important role in protecting the penis from viral and bacterial pathogens. The immunological functions of the human prepuce have been extensively documented by respected researchers for quite some time.<ref name="fleiss-hodges-vanhowe1998" />
* [[Development of retractable foreskin]]
* [[Foreskin]]
* [[Foreskin sensitivity]]
* [[Immunological protection of breastfeeding]]
* [[Keratinization]]