Changes

The '''preputial mucosa''' of the [[penis]] is the epithelium of the inside of the prepuce, or [[foreskin]]. To differentiate it from the cutaneous [[skin ]] of the outside of the [[Foreskin|prepuce]], it is sometimes referred to as the '''inner mucosa'''. It starts at the [[ridged band]] mucocutaneous junction at the tip of the [[Foreskin|prepuce]] and continues to the coronal sulcus (groove behind the [[glans penis]]), where it meets the epithelium of the glans and penile shaft.<ref name="cold-taylor1999">{{ColdCJ TaylorJR 1999}}</ref> The preputial mucosa is devoid of hair, as is the cutaneous surface.<ref name="taylor1996">{{TaylorJR LockwoodAP TaylorAJ 1996}}</ref> The preputial mucosa includes the [[ridged band]] and is richly endowed with [[Meissner's corpuscles]].<ref name="garcía-mesa2021">{{REFjournal |last=García-Mesa |first=Yolanda |init= |author-link= |last2=García-Piqueras |first2=Jorge |init2= |author2-link= |last3=Cobo |first3=Ramón |init3= |author3-link= |last4=Martín-Cruces |first4=José |init4= |author4-link= |last5=Suazo |first5=Iván |init5= |author5-link= |last6=García-Suárez |first6=Olivia |init6= |author6-link= |last7=Feito |first7=Jorge |init7= |author7-link= |last8= |first8=Vega |init8=José A. |author8-link= |etal=no |title=Sensory innervation of the human male prepuce: Meissner's corpuscles predominate |trans-title= |language= |journal=Journal of Anatomy |location= |date=2021-10 |volume=239 |issue=4 |article= |page= |pages=892-902 |url=https://onlinelibrary.wiley.com/doi/full/10.1111/joa.13481 |archived= |quote= |pubmedID=34120333 |pubmedCID=8450466 |DOI=10.1111/joa.13481 |accessdate=2022-03-18}}</ref>

Fleiss et al. (1998) report the inner [[mucosa ]] contains apocrine glands, which secrete cathepsin B, lysozyme, chymotrypsin, neutrophil elastase, and hormones such as androsterone. The first four substances have protective immunological functions.<ref name="fleiss-hodges-vanhowe1998">{{FleissP HodgesF VanHoweRS 1998}}</ref> After [[circumcision]], the residual [[mucosa]] is found between the [[circumcision scar]] and the [[glans penis]]. The [[mucosa]] is no longer moisturized by [[transudation]] from the [[foreskin]] and becomes desiccated and [[Keratinization|keratinized]]. Non-surgical [[foreskin restoration]] helps the mucosa to return to normal by [[dekeratinization]].  ==Care==Birley et al. (1993) recommended that the use of soap and excessive washing inside the [[foreskin]] be avoided.<ref>{{REFjournal |last=FleissBirley |init=PHDL |author-link=Paul M. Fleiss |last2=HodgesWalker |init2=FMM |author2-link=Frederick M. Hodges |last3=Van HoweLuzzi |init3=RSGA |author3-link=Robert S. Van Howe |last4=Bell |init4=R |author4-link= |etal=yes |title=Immunological functions Clinical Features and management of the human prepucerecurrentbalanitis; association with atopy and genitalwashing] |trans-title= |language= |journal=Sex Trans InfectGenitourin Med |location= |date=19981993-10 |volume=7469

|pages=364400-673 |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1758142/pdf/v074p00364.pdf

|pubmedID=101950348244363 |pubmedCID=1195128 |DOI=10.1136/sti.69.5.400 |accessdate=20192022-1202-0108}}</ref>

[[Category:GenitalsGenital]]