Changes

The '''preputial mucosa''' of the [[penis]] is the epithelium of the inside of the prepuce, or [[foreskin]]. To differentiate it from the cutaneous [[skin ]] of the outside of the [[Foreskin|prepuce]], it is sometimes referred to as the '''inner mucosa'''. It starts at the mucocutaneous junction at the tip of the [[Foreskin|prepuce]] and continues to the coronal sulcus (groove behind the [[glans penis]]), where it meets the epithelium of the glans and penile shaft.<ref name="cold-taylor1999">{{ColdCJ TaylorJR 1999}}</ref> The preputial mucosa is devoid of hair, as is the cutaneous surface.<ref name="taylor1996">{{TaylorJR LockwoodAP TaylorAJ 1996}}</ref> The preputial mucosa includes the [[ridged band]] and is richly endowed with [[Meissner's corpuscles]].<ref name="garcía-mesa2021">{{REFjournal |last=García-Mesa |first=Yolanda |init= |author-link= |last2=García-Piqueras |first2=Jorge |init2= |author2-link= |last3=Cobo |first3=Ramón |init3= |author3-link= |last4=Martín-Cruces |first4=José |init4= |author4-link= |last5=Suazo |first5=Iván |init5= |author5-link= |last6=García-Suárez |first6=Olivia |init6= |author6-link= |last7=Feito |first7=Jorge |init7= |author7-link= |last8= |first8=Vega |init8=José A. |author8-link= |etal=no |title=Sensory innervation of the human male prepuce: Meissner's corpuscles predominate |trans-title= |language= |journal=Journal of Anatomy |location= |date=2021-10 |volume=239 |issue=4 |article= |page= |pages=892-902 |url=https://onlinelibrary.wiley.com/doi/full/10.1111/joa.13481 |archived= |quote= |pubmedID=34120333 |pubmedCID=8450466 |DOI=10.1111/joa.13481 |accessdate=2022-03-18}}</ref> Fleiss et al. (1998) report the inner [[mucosa]] contains apocrine glands, which secrete cathepsin B, lysozyme, chymotrypsin, neutrophil elastase, and hormones such as androsterone. The first four substances have protective immunological functions.<ref name="fleiss-hodges-vanhowe1998">{{FleissP HodgesF VanHoweRS 1998}}</ref>

Fleiss After [[circumcision]], the residual [[mucosa]] is found between the [[circumcision scar]] and the [[glans penis]]. The [[mucosa]] is no longer moisturized by [[transudation]] from the [[foreskin]] and becomes desiccated and [[Keratinization|keratinized]]. Non-surgical [[foreskin restoration]] helps the mucosa to return to normal by [[dekeratinization]].  ==Care==Birley et al. (19981993) report recommended that the inner mucosa contains apocrine glands, which secrete cathepsin B, lysozyme, chymotrypsin, neutrophil elastase, use of soap and hormones such as androsterone. The first four substances have protective immunological functionsexcessive washing inside the [[foreskin]] be avoided.<ref name="fleiss-hodges-vanhowe1998">{{REFjournal |last=FleissBirley |init=PHDL |author-link=Paul M. Fleiss |last2=HodgesWalker |init2=FMM |author2-link=Frederick M. Hodges |last3=Van HoweLuzzi |init3=RSGA |author3-link=Robert S. Van Howe |last4=Bell |init4=R |author4-link= |etal=yes |title=Immunological functions Clinical Features and management of the human prepucerecurrentbalanitis; association with atopy and genitalwashing] |trans-title= |language= |journal=Sex Trans InfectGenitourin Med |location= |date=19981993-10 |volume=7469

|pages=364400-673 |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1758142/pdf/v074p00364.pdf

|pubmedID=101950348244363 |pubmedCID=1195128 |DOI=10.1136/sti.69.5.400 |accessdate=20192022-1202-0108