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* Cryotherapy is the use of extreme cold, usually with the application of liquid nitrogen, to freeze growths on the skin to kill the growth, which will then fall off. It is a common practice of dermatologists.
* CO<sub>2</sub> laser therapy under anesthesia destroys the PPP.<ref>{{REFweb |url=https://www.slideshare.net/slideshow/pearly-penile-papules-removal-with-a-co2-laser/18886189 |title=Pearly Penile Papules Removal with a CO<sub>2</sub> Laser |last=Anonymous |first= |init= |author-link= |publisher=Slideshare |date= |accessdate=2025-09-12}}</ref>
==Videos==