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| doi=10.1016/j.jdermsci.2005.08.009
| doi=10.1038/nm1541
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| pages=147-55
| url=
| DOI=10.1016/j.jdermsci.2005.08.009
| pubmedID=16226431
| accessdate=
}}</ref>, and this concept is one of the reasons behind the hypothesis that [http://intactipedia.org/index.php?title=Circumcision_and_HIV circumcision may reduce the risk of a male becoming infected with HIV from a female partner]. This Dutch study contradicts this idea, by stating that the Langerhans cells block HIV<ref name="de Witte-2007">{{REFjournal
| last=de Witte
| url=
| pubmedID=17334373
| DOI=10.1038/nm1541
| accessdate=
}}</ref>.