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using template DeWitte etal 2007
Although claims have been made that the presence of the foreskin increases the risk of infection with [[Circumcision and HIV|human immune deficiency virus]] ([[HIV]]), that is not correct. The claims are based on the reported findings of three randomized clinical trials (RCTs) that were carried out more than a decade ago in Africa. Boyle & Hill (2011) have shown these RCTs to be have significant methodological flaws and statistical errors that render their claims invalid.<ref name="boyle-hill2011">{{BoyleGJ HillG 2011}}</ref>
Fleiss et al. noted the presence of [[Langerhans cells]] in the prepuce.<ref name="fleiss-hodges-vanhowe1998"/> De Witte et al. (2007) have discovered that Langerhans cells produce ''Langerin'', which is a "natural barrier to [[HIV]] infection".<ref>{{REFjournal |last=de Witte |first=Lot |init=L |last2=Nabatov |first2=Alexey |init2=A |last3=Pion |first3=Marjorie |init3=M |last4=Fluitsma |first4=Donna |init4=D |last5=de Jong |first5=Marein A.W.P. |init5=MAWP |last6=de Gruijl |first6=Tanja |init6=T |last7=Piguet |first7=Vincent |init7=V |last8=van Kooyk |first8=Yvette |init8=Y |last9=Geijtenbeek |first9=Teunis B.H. |init9=TBH |title=Langerin is a natural barrier to HIV-1 transmission by Langerhans cells |journal=Nature Medicine |volume= |issue= |pages= |url=https://www.nature.com/articles/nm1541 |quote= |pubmedID=17334373 |pubmedCID= |DOI=10.1038/nm1541 |date=DeWitte etal 2007-03-04 |accessdate=2011-06-28}}</ref>
For more information, see [[Immunological and protective function of the foreskin]].