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Recent studies have shown this hypothesis to be false. One study found that there is "no difference between the keratinization of the inner and outer aspects of the adult male foreskin," and that "keratin layers alone were unlikely to explain why uncircumcised men are at higher risk for HIV infection."<ref>{{REFjournal
| last=Dinh | first=MH | coauthorslast2=McRaven MD, |first2=M.D. |last3=Kelley |first3=Z, . |last4=Penugonda |first4=S, . |last5=Hope TJ |first5=T.J. | title=Keratinization of the adult male foreskin and implications for male circumcision | journal=AIDS | volume=24 | issue=6 | pages=899-906 | url=http://www.ncbi.nlm.nih.gov/pubmed/20098294 | quote=We found no difference between the keratinization of the inner and outer aspects of the adult male foreskin. Keratin layers alone are unlikely to explain why uncircumcised men are at higher risk for HIV infection. | pubmedID=20098294 | pubmedCID= | DOI= | date=2010-03-27 | accessdate=
}}</ref> Another study found that "no difference can be clearly visualized between the inner and outer foreskin."<!-- <ref>{{REFcontribution
| contribution=HIV-1 Interactions and Infection in Adult Male Foreskin Explant Cultures