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Improve footnotes; Revise text to better reflect former and current views.
|date=1868
|accessdate=2010-10-20
}}</ref> Because of their dendritic nature, he mistakenly identified the cells as part of the nervous system.<ref name="omim-lch">{{OMIMREFweb |numberurl=https://omim.org/entry/604856 |title=Langerhans cell histiocytosis |trans-title= |language= |last=McKusick |first=Victor A |author-link= |publisher= |website=OMIM |date=2000-04-20 |accessdate=2019-10-20 |format= |quote=}}</ref>
==Function==
|issue=13
|pages=3119-31
|url=The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cellshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150992/
|quote=
|pubmedID=18086861
=== HIV ===
====Former hypothesis====
Kawamura ''et al''. (2005) suggested Langerhans cells have been indicted as may be initial cellular targets in the sexual transmission of HIV,<ref>{{REFjournal
|last=Kawamura
|first=Tatsuyoshi
|issue=3
|pages=147-55
|url=https://www.sciencedirect.com/science/article/pii/S0923181105002586
|quote=
|pubmedID=16226431
|pubmedCID=
|DOI=10.1016/j.jdermsci.2005.08.009
|date=2005-12 |accessdate=https://www.sciencedirect.com/science/article/pii/S0923181105002586
}}</ref> and as a target, reservoir, and vector of dissemination.<ref>{{REFjournal
|last=Dezutter-Dambuyant
|DOI=
|date=December 1995
|accessdate=2019-10-20
|language=French
}}</ref>
Hussain & Lehner (2005) observed Langerhans cells have been observed in foreskin, vaginal, and oral mucosa of humans; the lower concentrations in oral mucosa suggest that it is not a likely source of [[HIV]] infection relative to foreskin and vaginal mucosa.<ref name="pmid7558138">{{REFjournal
|last=Hussain
|first=L.A.
}}</ref>
====Present view==== On March 4, 2007 the online ''Nature Medicine '' magazine published the letter "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells."<ref>{{REFjournal
|last=De Witte
|first=Lot