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→Sensation and stimulation: Add text and citation.
|accessdate=
|note=
}}</ref> Repeated stimulation of this structure will cause orgasm and ejaculation in some men. In men with spinal cord injury preventing sensations from reaching the brain, for example, the frenulum just below the [[glans ]] can be stimulated to produce orgasm and peri-ejaculatory response.<ref>{{REFweb
| quote=
| url=http://www.emedicine.com/orthoped/topic425.htm
|accessdate=2021-03-11}}
</ref>
Cepeda-Emiliani et al (2023) state:
<blockquote>
One circumcision technique [91] has been proposed to protect
as much tissue as possible ventrally due to the sexual functions
attributed to this region. Concerningly and antithetically to the
former technique, the frenular area has been intentionally
targeted during [[adult circumcision]] by some urologists in
the belief that its total and permanent denervation using
monopolar current might be a definitive treatment for lifelong
premature ejaculation. These urologists concluded that
their circumcision technique resulted in “a consistent reduction
in penile sensitivity” and “is a strong weapon in the hands of
urological surgeons, which must be used very carefully, as its
effects on male sexuality can be devastating and irreversible
if performed in the wrong patient. Thus, the caveat must be
right circumcision in the right patient using the correct
surgical technique’”. To the extent that
this type of circumcision may impair sexual function by
denervating a neurologically permissive substrate through which
sexual sensation enters the central nervous system, we agree
with Jannini [93] that denervation of the frenular region is a
potentially dangerous intervention.<ref>{{REFjournal
|last=Cepeda-Emiliani
|first=
|init=A
|author-link=Alfonso Cepeda-Emiliani
|last2=Gándara-Cortés
|first2=
|init2=M
|author2-link=
|last3=Otero-Alén
|first3=
|init3=M
|author3-link=
|last4=García
|first4=
|init4=H
|author4-link=
|last5=Suárez-Quintanilla
|first5=
|init5=J
|author5-link=
|last6=García-Caballero
|first6=
|init6=T
|author6-link=
|last7=Gallego
|first7=
|init7=R
|author7-link=
|last8=García-Caballero
|first8=
|init8=R
|author8-link=
|etal=no
|title=Immunohistological study of the density and distribution of human penile neural tissue: gradient hypothesis
|trans-title=
|language=
|journal= Int J Impot Res
|location=
|date=2023-05-02
|volume=35
|issue=3
|article=
|page=
|pages=286-305
|url=https://www.nature.com/articles/s41443-022-00561-9
|archived=
|quote=
|pubmedID=35501394
|pubmedCID=
|DOI=10.1038/s41443-022-00561-9
|accessdate=2023-11-21
}}</ref>
</blockquote>
==Pathology==