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Foreskin

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The '''foreskin''' or '''prepuce''' is the double-layered fold of smooth muscle tissue, blood vessels, neurons, skin, and mucous membrane part of the [[penis ]] that covers and protects the glans penis and the urinary meatus.
The nature of the prepuce or foreskin, which is amputated and destroyed by circumcision, must be considered and fully understood in any discussion of male [[circumcision]].<ref name="cold-taylor1999">{{REFjournal
}}</ref>
Purpura ''et al.'' (2018) describe the foreskin as follows:<br><br><small><bblockquote>Few parts of the human anatomy can compare to the incredibly multifaceted nature of the human foreskin. At times dismissed as “just skin,” the adult foreskin is, in fact, a highly vascularized and densely innervated bilayer tissue, with a surface area of up to 90 cm, and potentially larger. On average, the foreskin accounts for 51% of the total length of the penile shaft skin and serves a multitude of functions. The tissue is highly dynamic and biomechanically functions like a roller bearing; during intercourse, the foreskin “unfolds” and glides as abrasive friction is reduced and lubricating fluids are retained. The sensitive foreskin is considered to be the primary erogenous zone of the male [[penis]] and is divided into four subsections: [[Preputial mucosa| inner mucosa]], [[ridged band]], [[frenulum]], and outer foreskin; each section contributes to a vast spectrum of sensory pleasure through the [[gliding action ]] of the foreskin, which mechanically stretches and stimulates the densely packed corpuscular receptors. Specialized immunological properties should be noted by the presence of Langerhans cells and other lytic materials, which defend against common microbes, and there is robust evidence supporting HIV protection. The [[glans penis| glans]] and inner mucosa are physically protected against external irritation and contaminants while maintaining a healthy, moist surface. The foreskin is also immensely vascularized and acts as a conduit for essential blood vessels within the penis, such as supplying the glans via the frenular artery.</b></small><ref>{{REFjournal
|last=Purpura
|first=Valeria
|etal=yes
|title=The development of a decellularized extracellular matrix–based biomaterial scaffold derived from human foreskin for the purpose of foreskin reconstruction in circumcised males
|trans-title=
|language=
|journal=J Tissue Eng
|location=
|DOI=10.1177/2041731418812613
|accessdate=2020-02-09
}}</ref> <br/blockquote
== Structure ==
===Foreskin in infancy and childhood===
Baby boys are born with the foreskin fused with the [[glans penis]] by the balanopreputial lamina, a [[synechia| synechial membrane]], which prevents retraction. In addition, the tip of the foreskin ([[acroposthion]]) is usually too narrow to allow [[retraction of the foreskin]]. The preputial cavity is closed by the synechia and cannot be infected.<ref name="fleiss-hodges-vanhowe1998"/>
Forcible attempts to retract the foreskin result in injury to the boy, so should be avoided. The first person to retract the foreskin should be the boy himself.<ref name="Wright1994">{{REFjournal |last=Wright |first=J.E. |title=Further to the "Further Fate of the Foreskin" |journal=Med J Aust |volume=160 |issue= |pages=134-135 |url=http://www.cirp.org/library/normal/wright2/ |quote= |pubmedID=8295581 |pubmedCID= |DOI= |date=1994-02-07 |accessdate=2020-05-16}}</ref>
Thorvaldsen & Meyhoff (2005) conducted a survey of 4,000 boys in Denmark. They report that the mean age of first foreskin retraction is 10.4 years in Denmark.<ref name="Thorvaldsen-meyhoff2005">{{REFjournal
|issue=
|pages=291-5
|url=httphttps://onlinelibrarywww.wileyarclaw.comorg/doiwp-content/10.1046uploads/j.1464Taylor-Prepuce-SpecMucosa-BJU-410X.1996.85023.x/fullpdf
|quote=
|pubmedID=8800902
|DOI=
|accessdate=2019-10-14
}}</ref>Taylor ''et al''. reported:<blockquote>The layer vascular ridges of the `ridged band' and its [[dartosMeissner's corpuscles]] muscle is contained within firmly separate preputial epithelium from true skin and place preputial mucosa amongst other mucocutaneous mucosae. Winkelmann emphasized the structural and functional importance of junctional regions of the foreskin.<ref name="coldbody and focused on mucocutaneous end-taylor1999 /> The dartos muscle keeps the foreskin snugly against organs, or `genital corpuscles', of the glanspenis and prepuce. Some of these end-organs resemble Krause end-bulbs; others resemble [[Meissner's corpuscles]]. The fibers … [[Meissner's corpuscles]] of the dartos muscle form prepuce may be compared with similar nerve-endings in the finger-tips and lips, which respond in a fraction of a whorl at the tip second to contact with light objects that functions as bring about deformation of their capsules. … The prepuce provides a sphincterlarge and important platform for several nerves and nerve endings. The sphincter opens innervation of the outer skin of the prepuce is impressive; its sensitivity to allow urine light touch and pain are similar to flow out, but closes to protect that of the skin of the penis from foreign matter, contaminants, and pathogensas a whole.<ref name="lakshmanan-prakash1980taylor1996"/><ref>{{REFjournal |last=Jefferson |first= |author-link= |title=The peripenic muscle; some observations on the anatomy of phimosis |journal=Surgery, Gynecology, and Obstetrics (Chicago) |date=1916 |volume=23 |issue=2 |pages=177-81 |url=http://www.cirp.org/library/anatomy/jefferson/ |quote= |pubmedID= |pubmedCID= |DOI= |accessdate=2019-10-14}}</refblockquote>
The [[ridged band]] area is found at the mucocutaneous junction. The ridged band area is characterized by rete ridges with Meissner’s [[Meissner's corpuscles ]] in the ridges.<ref name="taylor1996"/>
As with other neurologic structures such as the brain, the tip of the prepuce is richly supplied with blood by important vascular structures.<ref name="taylor1996"/> The prepuce serves as a conduit for several important veins.<ref name="fleiss-hodges-vanhowe1998">{{REFjournal
|DOI=10.1111/j.1464-410x.1995.tb07242.x
|accessdate=2019-10-15
}}</ref> The adult foreskin frequently has prominent visible veins.
 
The layer of [[dartos]] muscle is contained within the foreskin.<ref name="cold-taylor1999 /> The dartos muscle keeps the foreskin snugly against the glans. The fibers of the dartos muscle form a whorl at the tip that functions as a sphincter. The sphincter opens to allow urine to flow out, but closes to protect the penis from foreign matter, contaminants, and pathogens.<ref name="lakshmanan-prakash1980"/><ref>{{REFjournal
|last=Jefferson
|first=
|author-link=
|title=The peripenic muscle; some observations on the anatomy of phimosis
|journal=Surgery, Gynecology, and Obstetrics (Chicago)
|date=1916
|volume=23
|issue=2
|pages=177-81
|url=http://www.cirp.org/library/anatomy/jefferson/
|quote=
|pubmedID=
|pubmedCID=
|DOI=
|accessdate=2019-10-14
}}</ref>
 
The tapered tip of a longer foreskin that protrudes beyond the [[glans penis]] is known as the ''[[acroposthion]]''.
==Physiological functions==
 
Antique research by Alfred Kinsey (1948) and Masters & Johnson (1966) misled medical science into believing that the foreskin had no function. This meant the foreskin could be excised without doing harm. In actuality, the foreskin has many functions, so its amputation does great harm.
=== Protective functions ===
The foreskin provides physical protection to the [[glans penis ]] and inner mucosa, supplying moisture and natural oils by [[transudation]], protecting the mucosal tissue from pathogens, pollutants, friction, injury, [[keratinization]], and drying out. The foreskin protects the glans penis and meatus of infant boys from abrasion and irritation from ammoniacal diapers.<ref name="gairdner1949">{{REFjournal
|last=Gairdner
|first=D.
|url=https://www.researchgate.net/publication/230746332_Prepuce_in_boys_and_adolescents_What_when_and_how
|quote=
|pubmedID=22924249
|pubmedCID=
|DOI=10.2298/MPNS1208295D
}}</ref>
In the absence of the foreskin about ten to twenty percent of boys suffer urethral stricture ([[meatal stenosis]]) requiring further treatment.<ref name="frisch2016">{{REFjournal
|last=Frisch
|first=Morten
|first2=J.
|author2-link=
|title=Cultural background, non-therapeutic circumcision and the risk of meatal stenosis and other urethral stricture dis-easedisease: Two nationwide register-based cohort studies in Denmark 1977-2013
|trans-title=
|language=
|accessdate=2019-10-23
}}</ref> Frisch & Simonsen (2016) reported the incidence of meatal stenosis to be 3.7 times higher in circumcised boys.<ref name="frisch2016"/>
 
The foreskin continues to protect the glans penis throughout life, keeping it smooth, glossy, moist, sensitive, and free from [[keratinization]].
=== Immunological functions ===
The foreskin is highly vascularized. The high rate of blood flow helps to prevent infection.<ref name="fleiss-hodges-vanhowe1998"/>
Although claims have been made that the presence of the foreskin increases the risk of infection with [[Circumcision and Sexually Transmitted Diseases (STD)HIV| human immune deficiency virus]] (HIV), that is not correct. The claims are based on the reported findings of three randomized clinical trials (RCTs) that were carried out more than a decade ago in Africa. Boyle & Hill (2011) have shown these RCTs to be have significant methodological flaws and statistical errors that render their claims invalid.<ref name="boyle-hill2011">{{REFjournal
|last=Boyle
|first=Gregory J.
|accessdate=2011-06-28
}}</ref>
 
For more information, see [[Immunological and protective function of the foreskin]].
=== Sexual functions ===
The foreskin is a sexual organ. It provides both mechanical and erogenous functions in sexual intercourse.<ref name="fleiss-hodges-vanhowe1998"/> Winkelmann (1959) classified the foreskin as specific erogenous tissue.<ref name="winklemann1959" />{When the penis becomes erect, the foreskin unfolds to provide the skin necessary to allow the penis to expand to full size and length.
The [[gliding action]] provides stimulation and facilitates intromission.<ref name="warren-bigelow1994"/><ref name="morgan1965">{{REFjournal
|last=Morgan
|first=W.K.C.
===Sensory functions===
Nature designed the foreskin to be an erogenous sensory organ. The foreskin has a layer of muscle called the [[dartos]] muscle sheath that provides the foreskin with elasticity, flexibility, and stretchiness, which allows full stimulation of the nerves in the [[ridged band]] that sense movement and stretchingto provide [[foreskin sensitivity]]. There is a mucocutaneous region at the tip of the foreskin where outer skin changes to inner mucosa. Winklemann (1959) identified the foreskin as a ''specific erogenous zone'' (meaning an area of acute erogenous sensation). Winklemann reported rete ridges in the foreskin with nerves set close to the surface with closely set networks.<ref name="winklemann1959"/>
Lakshamanan & Prakash (1980) report the "prepuce covers the glans completely and snugly like a hosiered material and continues to do so through the entire span of life of the male", which they explain as being caused by the smooth muscle fibers within the prepuce. The prepuce is free to glide back and forth. When it does, it must stretch to go over the glans penis.<ref name="lakshmanan-prakash1980" />
Taylor ''et al.'' (1996) carried out a histological study of the foreskin. (Histology is the microscopic examination of cells and tissues.) Taylor ''et al''. found an area of rete ridges just inside the tip of the foreskin that he called the [[ridged band]]. The ridges were found to have nerve endings at the top of the ridges. They report that the ridged band area moves to the shaft of the penis when the penis becomes erect where the nerves are subject to stimulation. They stated:
<blockquote>
The prepuce provides a large and important platform for several nerves and nerve endings. The innervation of the outer skin of the prepuce is impressive; its sensitivity to light touch and pain are similar to that of the skin of the penis as a whole.<ref name="taylor1996" />
</blockquote>
}}</ref>
Cold & Taylor (1999) commented, "The increased frequency of [[masturbation]], anal intercourse and fellatio reported by circumcised men in the USA may possibly be due to the sensory imbalance caused by circumcision. Clearly, amputation of the prepuce causes changes in sexual behaviour in human males and females."<ref name="cold-taylor1999" />
Frisch ''et al''. (2013) surveyed the sexual function and behavior of a large group of intact and circumcised men in Denmark. They reported that "circumcised men were more likely (38%) than uncircumcised men (28%) to report ≥10 sex partners."<ref name="morten-lindholm2013">{{REFjournal
|DOI=10.1093/ije/dyr104
|accessdate=2019-10-23
}}</ref>
==The role of the foreskin in heterosexual relations==
Moses Maimonides, a Jewish rabbi and physician, stated in the 12th century:
{{Citation
|Text=''It is hard for a woman with whom an uncircumcised man has had sexual intercourse to separate from him''.
|Author=[[Moses Maimonides]]
|ref=<ref>{{REFbook
As previously reported, the foreskin reduces the force required for penetration of the female partner's vagina by as much as ninety percent.<ref name="taves2002"/> The gliding action of the foreskin reduces friction and abrasion, while conserving vaginal lubrication.<ref name="warren-bigelow1994"/>
In a first of its kind, O'Hara & O'Hara (1999) carried out a retrospective surevy survey of 138 women with experience of both intact and circumcised partners. The women overwhelmingly concurred that the mechanics of coitus was different for the two groups of men. Of the women, 73% reported that circumcised men tend to thrust harder and deeper, using elongated strokes, while unaltered men by comparison tended to thrust more gently, to have shorter thrusts, and tended to be in contact with the mons pubis and clitoris more, according to 71% of the respondents. Women with intact partners had a higher rate of orgasms than women with circumcised partners. O'Hara & O'Hara concluded:
<blockquote>Clearly, the anatomically complete penis offers a more rewarding experience for the female partner during coitus. While this study has some obvious methodological flaws, all the differences cannot be attributed to them. It is important that these findings be confirmed by a prospective study of a randomly selected population of women with experience with both types of men. It would be useful to examine the role of the foreskin in other sexual activities. Because these findings are of interest, the negative effect of circumcision on the sexual enjoyment of the female partner needs to be part of any discussions providing 'informed consent' before circumcision.<ref name="ohara1998">{{REFjournal
|last=O'Hara
The foreskin in childhood is fused with the glans penis by a [[synechia]].-->
{{SEEALSO}}
 
* [[Acroposthion]]
 
* [[Foreskin Care for Boys]]
 
* [[Foreskin in Motion]]
* [[Foreskin sensitivity]]
* [[Frenulum]]
 
* [[Immunological and protective function of the foreskin]]
 
* [[Retraction of the foreskin]]
 
* [[Ridged band]]
* [[The Foreskin and Why You Should Keep It (book)]]
{{LINKS}}
* {{REFweb |url=https://madsciencewriter.blogspot.com/2013/05/the-foreskin-why-is-it-such-secret-in.html?m=1 |archived= |title=The foreskin: Why is it such a secret in North America? |trans-title= |language= |last=Quine |first=Spoony |author-link= |publisher=Mad Science Writer |website= |date=2013-05-08 |accessdate=2020-04-19 |format= |quote=}}
* {{REFweb
|url=http://gaamerica.org/symposia/second/denniston2.html
|date=1991-05
|accessdate=2019-12-20
|format=
|quote=
}}
* {{REFweb
|url=http://www.intactaus.org/information/functionsoftheforeskin/
|archived=
|title=Functions of the Foreskin
|trans-title=
|language=English
|last=Hely
|first=Lou
|author-link=
|publisher=Intact Australia
|website=
|date=2014-08-01
|accessdate=2020-05-29
|format=
|quote=
}}
* {{REFweb
|url=https://circumcision.org/functions-of-the-foreskin/
|archived=
|title=Functions of the Foreskin
|trans-title=
|language=English
|last=Goldman
|first=Ronald
|author-link=Ronald Goldman
|publisher=Circumcision Resource Center
|website=circumcision.org
|date=
|accessdate=2020-07-01
|format=
|quote=
*{{REFweb
|url=http://www.foreskin.org/
|title=33 Photographs of the foreskin (Non-PornagraphicPornographic)
|trans-title=
|language=
|quote=
}}
 
* {{REFweb
|url=https://www.doctorsopposingcircumcision.org/for-professionals/the-prepuce/
|quote=To provide informed, respectful care to males with intact genitals, and to fully understand the harms of circumcision, health professionals must have a thorough grasp of the anatomy, development, and functions of the foreskin (also known as the prepuce).
}}
 
* {{REFweb
|url=http://www.circumstitions.com/Works.html
|quote=
}}
 
* {{REFweb
|url=http://www.intactaus.org/information/functionsoftheforeskin/
|title=Functions of the Foreskin
|trans-title=
|language=
|last=Hely
|first=Lou
|author-link=
|publisher=
|website=Intact Australia
|date=
|accessdate=2019-11-17
|format=
|quote=
}}
 
* {{REFweb
|url=https://www.i2researchhub.org/articles/ch-2-the-prepuce-doc-genital-integrity-statement/
|format=
|quote=
}}
* {{REFweb
|url=http://www.noharmm.org/advantage.htm
|title=The Foreskin Advantage
|first=Gary L
|last=Harryman
|publisher=NORM/Southern California
|website=[[NOHARMM]]
|accessdate=2020-06-30
}}
* {{REFjournal
|last=Fleiss
|first=Paul
|author-link=
|title=The foreskin is necessary
|journal=Mothering
|date=1997-01
|volume=
|issue=
|pages=36-45
|url=http://www.noharmm.org/mothering.htm
|accessdate=2020-06-29
}}
* [httphttps://www.noharmmforeskinfunction.org/advantage.htm The Foreskin AdvantageFunctions of the foreskin]
{{REF}}
[[Category:From IntactipediaForeskin anatomy]]
[[Category:Genitals]]
[[Category:Parental information]]
[[Category:Penile anatomy]]
 [[Category:Foreskin anatomyFrom Intactipedia]] 
[[de:Vorhaut]]
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