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→The immunological function of the foreskin: typo
|accessdate=2019-10-20
}}</ref> which is a very important non-antibody protein that generates immune response when in contact with specific agents. Plasma cells which increase in number in response to pathogens levels, secrete immunoglobulin.<ref name="flower1983"/>
It is also very important to note that Langerhans cells that are present in the foreskin produce ''Langerin'', a substance that has been proven to kill human immunodefiency viris immunodeficency virus (HIV) on contact.<ref>{{REFjournal
|last=de Witte
|first=L.