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Pain
,→Traumatic effect of infant circumcision: Add section.
|url=http://www.cirp.org/library/psych/rhinehart1/
|accessdate=2020-11-11
}}</ref>
===Effect of extreme pain on developing nervous system===
Fitzgerald & Walker (2003) hypothesized that extreme pain may alter developing nervous tissue in the very young.<ref>{{REFbook
|last=Fitzgerald
|first=Maria
|author-link=
|last2=Walker
|first2=Suellen
|author2-link=
|year=2003
|title=The role of activity in developing pain pathways
|url=http://www.cirp.org/library/pain/fitzgerald2/
|work=Proceedings of the 10th World Congress on Pain
|editor=Dostovsky JO, Carr DB, Koltzenburg M (eds)
|edition=
|volume=24
|chapter=
|pages=185-96
|location=Seattle
|publisher=ASP Press
|isbn=
|quote=In common with other areas of the central nervous system, synaptic development of spinal sensory connections is experience or activity dependent. Evidence from both animal and human studies shows that alterations in the patterns of sensory activity that can arise from tissue injury and pain in early life may disrupt normal synaptic organization within the somatosensory system. While these studies are incomplete and more investigation is needed in this area, the potential clinical importance of neonatal plasticity in pain development is clear.
|accessdate=2020-11-18
|note=
}}</ref>