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}}</ref> Genital herpes, often simply known as herpes, may have minimal symptoms or form blisters that break open and result in small ulcers. These typically heal over two to four weeks. Tingling or shooting pains may occur before the blisters appear. Herpes cycles between periods of active disease followed by periods without symptoms. The first episode is often more severe and may be associated with fever, muscle pains, swollen lymph nodes and headaches. Over time, episodes of active disease decrease in frequency and severity. Other disorders caused by herpes simplex include: herpetic whitlow when it involves the fingers,<ref>{{REFjournal
|last=Wu
|firstinit=I.B.IB
|last2=Schwartz
|first2init2=R.A.RA
|title=Herpetic whitlow
|journal=Cutis
}}</ref> herpes of the eye,<ref>{{REFjournal
|last=Rowe
|firstinit=A.M.AM
|last2=St Leger
|first2init2=A.J.AJ
|last3=Jeon
|first3init3=S.
|last4=Dhaliwal
|first4init4=D.K.DK
|last5=Knickelbein
|first5init5=J.E.JE
|last6=Hendricks
|first6init6=R.L.RL
|title=Herpes keratitis
|journal=Progress in Retinal and Eye Research
}}</ref> '''herpes infection of the brain''',<ref>{{REFjournal
|last=Steiner
|firstinit=I.
|last2=Benninger
|first2init2=F.
|title=Update on herpes virus infections of the nervous system
|journal=Current Neurology and Neuroscience Reports
}}</ref> and '''neonatal herpes''' when it affects a newborn, among others.<ref>{{REFjournal
|last=Stephenson-Famy
|first1init=A.
|last2=Gardella
|first2init2=C.
|title=Herpes Simplex Virus Infection During Pregnancy
|journal=Obstetrics and Gynecology Clinics of North America