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Circumcision advocates of the past who alleged a relationship between "lack of circumcision" and genital cancers formerly implicated smegma or smegma-borne pathogens as the causative agent. Only two histologic studies of human smegma have ever been conducted, both of which found it to be perfectly harmless.
The hypothesis that human male smegma is carcinogenic was first formulated in 1932 by circumcision promoter [[Abraham L. Wolbarst]], M.D.{{MD}}<ref>{{REFjournal
|last=Wolbarst
|init=AL