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After he examined the patient though, Sayre concluded that "the deformity was due to paralysis and not contraction, and it was therefore necessary to restore vitality to the partially paralyzed extensor muscles, rather than to cut the apparently contracted flexors." But the cause of this paralysis was a mystery. There was no history of injury and seemed to be no other symptoms of disease. Puzzled and determined to trace the problem to its source, he finally decided to test the boy's reflexes by applying electric current to his legs. While he was doing this, the child's nurse exclaimed, "Oh, doctor! be very careful - don't touch his pee-pee - it's very sore." An examination of the patient's genitals showed that the penis was normal, except that "the glans was very small and pointed, tightly imprisoned in the contracted foreskin, and in its efforts to escape, the meatus urinarius had become as puffed out and red as in a case of severe granular urethritis." This was, according to the nurse, a chronic condition. Often the pain awaked him at night, the child's genitals having become so sensitive that even the slight friction of bedclothes caused painful erections. Pondering this information, Sayre suddenly imagined that he knew the source of the boy's problem. "As excessive venery is a fruitful source of physical prostration and nervous exhaustion, sometimes producing paralysis," he explained afterward, "I was disposed to look upon this case in the same light, and recommended circumcision as a means of relieving the irritated and imprisoned penis."
He was so confident of his diagnosis that he brought the boy to Bellevue Hospital in order to demonstrate the operation to his students there. The following day, after the patient was anesthetized, Sayre drew the foreskin forward and cut it with scissors. To his surprise, "the mucous portion [remained] quite firmly adherent to the glans nearly to the orifice of the [[urethra]]." So he finished the procedure by "seizing the thickened mucous membrane with the thumbs and finger nails of each hand" and tearing it away from the glans. Whatever it may have lacked in elegance, this operation seemed to produce a wonderful result. From the first day, the child's health began to improve. Color returned to his cheeks. Soon he regained his appetite, slept soundly and, most remarkable of all, within a few weeks "was able to walk with his limbs quite straight." Improbable as it seemed, Sayre postulated that "simply quieting his nervous system by relieving his imprisoned glans penis" circumcision had restored the young patient's health.<ref name="gollaher1994">{{GollaherDL 1994}}</ref>
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