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→Hair Stimulating Complex: Add sale of Shire.
HSC contains proteins, chemicals called growth factors and other substances produced by [[skin]] cells called fibroblasts. The substances are produced when the cells are grown in a low-oxygen environment mimicking an embryonic environment.
The fibroblasts are taken from neonatal foreskins, the byproduct of circumcisions. These are the same cells used by the defunct San Diego company Advanced Tissue Sciences, which produced a living [[skin]] product called Dermagraft It's not a coincidence: Naughton was president and COO of the company. Dermagraft is now being made in San Diego by a subsidiary of Shire, a medical company based in Dublin, Ireland.<ref name="hairgrowth"/>Shire was sold to Takeda Pharmaceutical Company on 8 January 2019.
The United States Patent & Trademark Office issued patent 8,257,947, entitled "Extracellular Matrix Compositions Produced Under Hypoxic Culture Conditions" to Histogen. The patent, which is the Company's first patent issued in the United States, covers Histogen's method of growing cells under low oxygen and suspension conditions, and the process through which the naturally-secreted protein compositions are produced.<ref name="hairgrowth"/>