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|date=2012
|accessdate=2022-10-07
}}</ref> The preputial cavity may also be called the '''sub-preputial space'''. The preputial sac is lined with [[mucosa]] as is appropriate for an internal locationorgan.
Moistness is maintained by [[transudation]]. Parkash et al. (1973) reported that epithelial debris accumulates in the preputial sac and forms [[smegma]].<ref name="parkash1873">{{REFjournal
}}</ref>, a natural, normal, benign, healthy, and beneficial product of the body, which will collect in the preputial sac.
Parkash et al. (1982) studied the wetness to learn its source. The authors concluded "that the space is kept moist and also clean in those with preputial stenosis, by the secretions of the prostate, supplemented by the seminal secretion of the mucin content of the secretion of the urethral glands."<refname="parkash1982">{{REFjournal
|last=Parkash
|first=
|pubmedCID=
|DOI=
|accessdate=2022-10-07
}}</ref> The authors further reported that the wetness is rich in lytic material.<ref name="parkash1982" /> Lytic material causes lysis or a breakdown of organisms.<ref>{{REFweb
|url=https://medical-dictionary.thefreedictionary.com/lytic
|title=Lytic
|publisher=The Free Dictionary by Farlex
|date=2012
|accessdate=2022-10-07
}}</ref>