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The preputial sac is lined with [[mucosa]] as is appropriate for an internal organ.
Moistness is may be maintained by [[transudation]]. Parkash et al. (1973) reported that epithelial debris accumulates in the preputial sac and forms [[smegma]].<ref name="parkash1873">{{REFjournal
|last=Parkash
|first=
|DOI=
|accessdate=2022-10-07
}}</ref> The authors further reported that the wetness is rich in lytic material.<ref name="parkash1982" /> Lytic material causes lysis or a breakdown of organismscell walls.<ref>{{REFweb
|url=https://medical-dictionary.thefreedictionary.com/lytic
|title=Lytic
|date=2012
|accessdate=2022-10-07
}}</ref> Wetness is associated with having a longer prepuce.<ref name="ofarrell2008">{{REFjournal |last=O'Farrell |first= |init=N |author-link= |last2=Chung |first2= |init2=CK |author2-link= |last3=Weiss |first3=Helen |init3= |author3-link= |etal=no |title=Foreskin length in uncircumcised men is associated with subpreputial wetness |trans-title= |language= |journal= Int J STD AIDS. |location= |date=2008-12 |season= |volume=19 |issue=23 |pages=821-3 |url= |archived= |quote= |pubmedID=19050212 |pubmedCID= |DOI=10.1258/ijsa.2008.008106 |accessdate=2022-10-07}}</ref>