Changes

The results of this study are consistent with studies of pain response in animals and behavioural studies in humans showing that injury and tissue damage sustained in infancy can cause sustained changes in central neural function, which persist after the wound has healed and influence behavioural responses to painful events months later. Pretreatment and postoperative management of neonatal circumcision pain is recommended based on these results. Investigation of the neurological basis of these effects is warranted.<ref name="taddio1997">{{REFjournal |last=Taddio |first=Anna |init=A |author-link= |last2=Katz |first2=Joel |init2=J |author2-link= |last3=Ilersich |first3=A. Lane |init3=AL |author3-link= |last4=Koren |first4=Gideon |init4=K |author4-link= |etal=no |title=Effect of neonatal circumcision on pain response during subsequent routine vaccination |journal=Lancet |location= |date=1997-03-01 |volume=349 |issue=9052 |pages=599-603 |url=http://www.cirp.org/library/pain/taddio2/ |quote= |pubmedID=9057731 |pubmedCID= |DOI=10.1016/S0140-6736(96)10316-0 |accessdate=2019-12-08}}</ref>