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|pubmedCID=5131839
|pubmedID=27494386
}}</ref> The initial symptoms are typically a feeling of cold and tingling or numbing.<ref name=Handford2017/> This may be followed by clumsiness with a white or bluish color to the [[skin]].<ref name=Handford2017/> Swelling or blistering may occur following treatment.<ref name=Handford2017/> Complications may include hypothermia or compartment syndrome.<ref name=Mc2014>{{REFjournal
|last=McIntosh
|first=Scott E.