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Bill & Melinda Gates Foundation

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These articles and the core study are specially intriguing because traditionally it was thought that the [http://intactipedia.org/index.php?title=Langerhans_cells Langerhans cells] of the [http://intactipedia.org/index.php?title=Foreskin Prepuce (foreskin)] constituted an entry point for HIV<ref name="Kawamura-2005">{{REFjournal
| last=Kawamura | first=T. | coauthorslast2=Kurtz SE |first2=S., E. |last3=Blauvelt |first3=A., |last4=Shimada |first4=S. | date=2005, Dec. | title=The role of Langerhans cells in the sexual transmission of HIV. | journal=J Dermatol Sci | volume=40 | issue=3 | pages=147-55 | url= | DOI=10.1016/j.jdermsci.2005.08.009 | pubmedID=16226431 | accessdate=
}}</ref>, and this concept is one of the reasons behind the hypothesis that [http://intactipedia.org/index.php?title=Circumcision_and_HIV circumcision may reduce the risk of a male becoming infected with HIV from a female partner]. This Dutch study contradicts this idea, by stating that the Langerhans cells block HIV<ref name="de Witte-2007">{{REFjournal
| last=de Witte | first=L. | coauthorslast2=Nabatov |first2=A., |last3=Pion |first3=M., |last4=Fluitsma |first4=D., |last5=de Jong MA |first5=M.A., |last6=de Gruijl |first6=T., |last7=Piguet |first7=V., |last8=van Kooyk |first8=Y., |last9=Geijtenbeek TB |first9=T.B. | date=2007, March | title=Langerin is a natural barrier to HIV-1 transmission by Langerhans cells. | journal=Nat Med | volume=13 | issue=3 | pages=367-71 | url= | pubmedID=17334373 | DOI=10.1038/nm1541 | accessdate=
}}</ref>.
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