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In the genitally intact penis the urine stream flushes out the urethra and foreskin of foreign microbes. In healthy individuals, urine is sterile and has a disinfectant quality. Researchers have demonstrated that the swirling action of urine as it rushes through the foreskin flushes it out effortlessly and naturally.<ref name="parkash-jeykumar1973">Parkash S, Jeykumar S, Subramanyan K, Chaudhuri S. [http://www.cirp.org/library/anatomy/parkash/ Human Subpreputial collection: its nature and formation]. ''J Urol'' 1973 Aug 110(2):211-2</ref>
Cleaning up document.
The [[foreskin]], like the eyelid, also serves an important protective and hygienic function. The foreskin protects the delicate glans of the [[penis]] and puts the urethra at a distance form its environment, protecting it from foreign contaminants of all kinds while simultaneously shielding the penis from injury. It is a double fold of skin which offers two layers of protection.
Natural secretions of oil are achieved by sebaceous glands which are abound in the foreskins foreskin's inner lining, these are not present in the [[glans penis]].<ref name="hyman-brownstein1969">Hyman AB, Brownstein MH. [https://jamanetwork.com/journals/jamadermatology/article-abstract/530842 Tyson's "glands": ectopic sebaceous glands and papillomatosis penis]. ''Arch Dermatol'' . 1969 Jan;99(1):31-6.</ref> They are also present in the eye lid and perform the same function in both places. They secrete the oils necessary to keep the glans surface soft, moist, smooth, warm, sensitive, and with a healthy glistening red or purple color. This moisturizer also maintains PH balance, and optimal cleanliness. This is required to keep the surface of the glans healthy and clean via the cleaning effects of mucous secretions. Again, this function is analogous to the eye lid. The glans penis is meant to be an internal organ covered and protected from the outside world. In the genitally intact penis the urine stream flushes out the urethra and foreskin of foreign microbes. In healthy individuals, urine is sterile and has a disinfectant quality. Researchers have demonstrated that the swirling action of urine as it rushes through the foreskin flushes it out effortlessly and naturally.<ref name="parkash-jeykumar1973">Parkash S, Jeykumar S, Subramanyan K, Chaudhuri S. [http://www.cirp.org/library/anatomy/parkash/ Human Subpreputial collection: its nature and formation]. ''J Urol''. 1973 Aug 110(2):211-2</ref>
Though urine passes through the foreskin every day, the inner foreskin is remarkably free of urea — a by-product of liver metabolism that is secreted in urine. Studies demonstrate that washings from the foreskin are rich in fructose, acid phosphatase, and mucin, but never urea. It appears that the secretions of seminal vesicles, prostate, and urethral mucous glands, collectively or individually, keep the foreskin clear and clean as well.<ref>Parkash S. Penis: some facts and fancies. ''Journal of Physician's Association 0f Madras'' June 1982: 1-13.</ref>
At birth, the foreskin is usually attached to the glans(head) of the penis, akin to how a fingernail is attached to a finger.<ref>Diebert GA. [http://www.cirp.org/library/anatomy/deibert/ The separation of the prepuce in the human penis]. ''Anatomical Record'' . 1993 Nov;57(4):387-99.</ref>
In infancy the foreskin's tubular neck (prepucial orifice) is often long and narrow while the sphincter muscle in the tip of the foreskin keeps its opening closed. This acts as an extension of the urethra.<ref>Hunter RH. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1249280/pdf/janat00534-0090.pdf Notes on the development of the prepuce]. ''Journal of Anatomy'' . 1935 Oct;70(1):6875.</ref> <ref>Glenister TW. A consideration of their process involved in the development of the prepuce in man. ''Br J Urol'' . 1956 Sep;28(3):243-9.</ref>
Together, these properties prevent the entry of contaminants.
The idea that the foreskin is "dirty" or "unclean" is a scientifically unfounded superstition. The intact penis is naturally clean and maintains a level of hygiene that is optimal when compared to a penis that has been altered by circumcision.
plasma cells<ref>Flower PJ, Ladds PW, Thomas AD, Watson DL. An immunopathologic study on the bovine prepuce. ''Vet Pathol'' 1983 Mar;20(2):189-201.</ref>
apocrine glands,<ref> Ahmed A, Jones AW. Apocrine Cystadenoma: a report of two cases occurring on the prepuce. ''Br J Dermatol'' 1969 Dec; 81(12):899-901.</ref>
and sebaceous glands,<ref>Hyman AB, Brownstein MH. Tyson's "glands": ectopic sebaceous glands and papillomatosis penis. ''Arch Dermatol'' 1969 Jan;99(1):31-6</ref> <ref>Delbanco E. Über das gehäufte Aufreten von Talgdrusen an der Innerflähe des Präputium. ''Monatshefte für praktishe Dermatologie'' 1904; 38:536-8.</ref> <ref>Piccinno R, Carrel C-F, Menni S. ''et al''. sebacous glands mimicking molluscum contagiosum ''Acta Derm Venerol'' 1990;70:344-5.</ref> <ref>Krompecher St. Die Histologie der Absonderung fur Smegma Praeputi. ''Anatomischer Anzeiger'' 1932; 75:170-17676.</ref>, collectively secrete emolliating emolliante lubricants.<ref>Parkash S, Jeykumar S, Subramanyan K, Chaudhuri S. Human Subpreputial collection: its nature and formation. ''J Urol'' 1973 Aug 110(2):211-2.</ref> Apocrine glans perform a crucial function by secreting enzymes such as lysosomal enzymes, cathepsin B, chymotrypsin, and neutrophil elastase.<ref>Frohlich E Shamburg-Lever G, Klesses C. Immunelectron microscopic localization of cathepsin B in human apocrine glands. ''J Cutan Pathol'' 1993 Feb;20(1):54-60</ref>
There is also strong research to suggest that lysozyme can protect against HIV infection'
<ref>George Hill. [http://www.cirp.org/library/disease/HIV/hill1/ Summary of evidence that the foreskin and lysozyme may protect against HIV infection]. 7 September 2003. </ref>
Apocrine glands also produce cytokine,<ref>Ahmed AA, Nordlind K, Schultzberd M, Liden S. Immunohisto chemical localization of IL-1 alpha-, IL-1 beta-, IL-6- and TNF-alpha-like immunoreactivities in human apocrine glands Arch</ref>
which is a very important nonantibody protein that generates immune response when in contact with specific agents.
Plasma cells which increase in number in response to pathogens levels, secrete immunoglobulin.
<ref>Flower PJ, Ladds PW, Thomas AD, Watson DL. [https://journals.sagepub.com/doi/abs/10.1177/030098588302000206 An immunopathologic study on the bovine prepuce]. ''Vet Pathol'' 1983 Mar;20(2):189-201.</ref>
It is also very important to note that [[Langerhans cells ]] that are present in the foreskin produce ''Langerin'', a substance that has been proven to kill the HI-virus on contact.<ref> de Witte L, Nabatov A, Pion M, ''et al''. [http://www.cirp.org/news/healthday2007-03-05/ Langerin is a natural barrier to HIV-1 transmission by Langerhans cells]. ''Nat Med'' 2007 Mar;13(3):367-71.</ref>
All of these function to sequester and “digest” foreign pathogens. All these substances play an important role in protecting the penis from viral and bacterial pathogens. The immunological functions of the human prepuce have been extensively documented by respected researchers for quite some time.<ref>Fleiss PM, Hodges FM, Van Howe RS. [http://www.cirp.org/library/disease/STD/fleiss3/ Immunological functions of the human prepuce]. ''Sex Trans Infect'' (London), Volume 74, Number 5, Pages 364-367, October 1998.</ref>
In infancy, simple sugars in breast milk, like antibacterial oligosaccharides, are acquired from the mothers mother's milk and excreted in urine. University studies have shown that these substances cling to the mucosal lining of the inner foreskin and protect against urinary tract infections,<ref>Hanson LA, Karlsson B, Jalil F, ''et al''. Antiviral and antibacterial factors in human milk. In: Hanson LA, ed. ''Biology of Human Milk''. New York Raven Press; 1988. pp. 141-57</ref> as well as infections in other parts of the body.<ref>Coppa GV, Gabrielli O, Giorgi P, Catassi C, Montanari MP, Veraldo PE, Nichols BL. Preliminary study of breast feeding and bacterial adhesion to uroepithelial cells. ''Lancet'' 1990 Mar 10;335(8689):569-71.</ref> Babies excrete in their urine about 300-500 milligrams of oligosaccharides each day. These compounds prevent virulent strains of Escherichia coli from adhering to the mucosal lining of the entire urinary tract, including the foreskin and glans. For these reasons breast-milk is highly efficacious at preventing UTI.<ref>Gothefors L, Olling S, Winberg J. Breastfeeding and biological properties of faecal E. coli strains. ''Acta Paediatr Scand'' 1975 Nov;54(6):807-12.</ref> Rigorous study's have repeatedly demonstrated that breast feeding protects against urinary tract infections.<ref>Mårild S. Breastfeeding and Urinary Tract Infections. ''Lancet'' 1990;336:942.</ref> <ref>Pisacane A, ''et al''. Breastfeeding and urinary tract infection. ''The Lancet'', July 7, 1990, p50 </ref> <ref>Pisacane A, Graziano L, Mazzarella G, ''et al''. Breast-feeding and urinary tract infection. ''J Pediatr'' 1992;120:87-89.</ref>
Researchers have shown that premature foreskin retraction can expose the penis to hospital strains of Escherichia coli and can result in UTI.<ref>Winberg J ''et al''. The Prepuce: A Mistake of Nature? ''Lancet'' 1989, pp.598-99.</ref> Hence the protective function of the foreskin is in the child's best interest especially during chemically treated diaper wearing years where feces mixed with urine can not only contaminate the permanently exposed urinary meatus but also the amputation wound from the circumcision surgery itself.