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using template LanderJ etal 1997
 
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  |date=2005
  |date=2005
  |accessdate=2023-11-24
  |accessdate=2023-11-24
}}</ref> EMLA® was the least-effective of the three analgesia methods studied.<ref name="lander1997">{{REFjournal
}}</ref> EMLA® was the least-effective of the three analgesia methods studied.<ref name="lander1997">{{LanderJ etal 1997}}</ref>
|last=Lander
|init=J
|first=Janice
|author-link=
|last2=Brady-Frerer
|init2=B
|first2=Barbara
|author2-link=
|last3=Metcalfe
|init3=JB
|first3=James B.
|author3-link=
|last4=Nazerali
|init4=S
|first4=Shermin
|author4-link=
|last5=Muttit
|init5=S
|first5=Sarah
|author5-link=
|etal=no
|title= Comparison of ring block, dorsal penile nerve block, and topical anesthesia for neonatal circumcision
|journal=JAMA
|location=
|date=1997-12-24
|volume=278
|issue=24
|pages=2157-64
|url=http://www.cirp.org/library/pain/lander/
|archived=
|quote=
|pubmedID=9417009
|pubmedCID=
|DOI=
|accessdate=2023-12-01
}}</ref>


Before the specification of the approval in 2013, EMLA® ointment was often used in the so-called ''off-label use''<ref>{{REFweb
Before the specification of the approval in 2013, EMLA® ointment was often used in the so-called ''off-label use''<ref>{{REFweb
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}}</ref>
}}</ref>


Various studies come to the conclusion that EMLA-circumcisions of young children are not suitable to sufficiently exclude the [[pain]].<ref>{{REFjournal
The conclusion of various studies show that the effectiveness of EMLA® is not sufficient to exclude the [[pain]] of non-therapeutic infant [[circumcision]].<ref name="lander1997" /> <ref>{{REFjournal
  |title=Does topical Amethocaine cream increase first-Time successful cannulation in children compared with a eutectic mixture of local anaesthetics (EMLA) cream? A systematic review and meta-analysis of randomised controlled trials
  |title=Does topical Amethocaine cream increase first-Time successful cannulation in children compared with a eutectic mixture of local anaesthetics (EMLA) cream? A systematic review and meta-analysis of randomised controlled trials
  |url=https://www.researchgate.net/publication/267728942
  |url=https://www.researchgate.net/publication/267728942
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  |DOI=10.1136/emermed-2014-204066
  |DOI=10.1136/emermed-2014-204066
  |accessdate=2020-12-19
  |accessdate=2020-12-19
}}</ref><ref>{{REFjournal
}}</ref> <ref>{{REFjournal
  |url=https://pubmed.ncbi.nlm.nih.gov/30587535/
  |url=https://pubmed.ncbi.nlm.nih.gov/30587535/
  |title=Efficacy and Safety of EMLA Cream for Pain Control Due to Venipuncture in Infants: A Meta-analysis
  |title=Efficacy and Safety of EMLA Cream for Pain Control Due to Venipuncture in Infants: A Meta-analysis
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  |accessdate=2020-12-21
  |accessdate=2020-12-21
}}</ref>
}}</ref>
{{SEEALSO}}
{{SEEALSO}}
* [[Pain]]
* [[Pain]]


{{REF}}
{{REF}}


[[Category:Acronym]]
[[Category:Acronym]]
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