EMLA: Difference between revisions

Line 36:

== History ==

Before the specification of the approval in 2013, ~~EMLA~~ ointment was often used in the so-called ''off-label use''<ref>{{REFweb

Lander et al. (1997) did a comparison study of EMLA® cream topical anesthetic.<ref>{{REFweb

|url=https://medical-dictionary.thefreedictionary.com/Emla+cream

|title=Emla cream

|last=Anonymous

|publisher=The Free Dictionary by Farley

|date=2005

|accessdate=2023-11-24

}}</ref> EMLA® was the least-effective of the three analgesia methods studied.<ref name="lander1997">{{REFjournal

|last=Lander

|init=J

|first=Janice

|author-link=

|last2=Brady-Frerer

|init2=B

|first2=Barbara

|author2-link=

|last3=Metcalfe

|init3=JB

|first3=James B.

|author3-link=

|last4=Nazerali

|init4=S

|first4=Shermin

|author4-link=

|last5=Muttit

|init5=S

|first5=Sarah

|author5-link=

|etal=no

|title= Comparison of ring block, dorsal penile nerve block, and topical anesthesia for neonatal circumcision

|journal=JAMA

|location=

|date=1997-12-24

|volume=278

|issue=24

|pages=2157-64

|url=http://www.cirp.org/library/pain/lander/

|archived=

|quote=

|pubmedID=9417009

|pubmedCID=

|DOI=

|accessdate=2023-12-01

}}</ref>

Before the specification of the approval in 2013, EMLA® ointment was often used in the so-called ''off-label use''<ref>{{REFweb

|url=https://en.wikipedia.org/wiki/Off-label_use

|title=Off-Label use

|website=Wikipedia

|accessdate=2022-07-27

}}</ref> in neonatal circumcision. In addition, ~~EMLA~~ ointment does not require a prescription and can therefore be purchased over the counter. As a result, a medical risk assessment for off-label use is not guaranteed. Even less can it be assumed that the partly non-physician group of people who use EMLA® ointment for newborn circumcision recognizes the symptoms of toxic drug levels in the newborn, let alone masters them.<ref name="Wakankar 2014-02-18">{{REFweb

}}</ref> in neonatal circumcision. In addition, EMLA® ointment does not require a prescription and can therefore be purchased over the counter. As a result, a medical risk assessment for off-label use is not guaranteed. Even less can it be assumed that the partly non-physician group of people who use EMLA® ointment for newborn circumcision recognizes the symptoms of toxic drug levels in the newborn, let alone masters them.<ref name="Wakankar 2014-02-18">{{REFweb

|url=https://www.beschneidungsforum.de/thread/2353-buchver%C3%B6ffentlichung-mit-einem-beitrag-von-j%C3%A9r%C3%B4me-segal-herausgeber-prof-matthia/?postID=27504#post27504

|title=Die Beschneidung von Jungen, ein trauriges Vermächtnis

@@ Line 36: / Line 36: @@
 == History ==
-Before the specification of the approval in 2013, EMLA ointment was often used in the so-called ''off-label use''<ref>{{REFweb
+Lander et al. (1997) did a comparison study of EMLA® cream topical anesthetic.<ref>{{REFweb
+ |url=https://medical-dictionary.thefreedictionary.com/Emla+cream
+ |title=Emla cream
+ |last=Anonymous
+ |publisher=The Free Dictionary by Farley
+ |date=2005
+ |accessdate=2023-11-24
+}}</ref> EMLA® was the least-effective of the three analgesia methods studied.<ref name="lander1997">{{REFjournal
+ |last=Lander
+ |init=J
+ |first=Janice
+ |author-link=
+ |last2=Brady-Frerer
+ |init2=B
+ |first2=Barbara
+ |author2-link=
+ |last3=Metcalfe
+ |init3=JB
+ |first3=James B.
+ |author3-link=
+ |last4=Nazerali
+ |init4=S
+ |first4=Shermin
+ |author4-link=
+ |last5=Muttit
+ |init5=S
+ |first5=Sarah
+ |author5-link=
+ |etal=no
+ |title= Comparison of ring block, dorsal penile nerve block, and topical anesthesia for neonatal circumcision
+ |journal=JAMA
+ |location=
+ |date=1997-12-24
+ |volume=278
+ |issue=24
+ |pages=2157-64
+ |url=http://www.cirp.org/library/pain/lander/
+ |archived=
+ |quote=
+ |pubmedID=9417009
+ |pubmedCID=
+ |DOI=
+ |accessdate=2023-12-01
+}}</ref>
+Before the specification of the approval in 2013, EMLA® ointment was often used in the so-called ''off-label use''<ref>{{REFweb
   |url=https://en.wikipedia.org/wiki/Off-label_use
   |title=Off-Label use
   |website=Wikipedia
   |accessdate=2022-07-27
-}}</ref> in neonatal circumcision. In addition, EMLA ointment does not require a prescription and can therefore be purchased over the counter. As a result, a medical risk assessment for off-label use is not guaranteed. Even less can it be assumed that the partly non-physician group of people who use EMLA® ointment for newborn circumcision recognizes the symptoms of toxic drug levels in the newborn, let alone masters them.<ref name="Wakankar 2014-02-18">{{REFweb
+}}</ref> in neonatal circumcision. In addition, EMLA® ointment does not require a prescription and can therefore be purchased over the counter. As a result, a medical risk assessment for off-label use is not guaranteed. Even less can it be assumed that the partly non-physician group of people who use EMLA® ointment for newborn circumcision recognizes the symptoms of toxic drug levels in the newborn, let alone masters them.<ref name="Wakankar 2014-02-18">{{REFweb
   |url=https://www.beschneidungsforum.de/thread/2353-buchver%C3%B6ffentlichung-mit-einem-beitrag-von-j%C3%A9r%C3%B4me-segal-herausgeber-prof-matthia/?postID=27504#post27504
   |title=Die Beschneidung von Jungen, ein trauriges Vermächtnis