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== Regeneration of the foreskin ==
Recently there has been growing interest in regenerative medicine as a means to regenerate the human male foreskin. This option, unlike foreskin restoration, would result in a true human male foreskin being regrown.
In early 2010, [[Foregen]], a non-profit organization dedicated to funding a clinical trial for the purposes of regrowing the human male foreskin, had been founded. A clinical trial had been scheduled for late 2010, but there were insufficient donations to follow through.<ref>{{REFjournal
|last=
|first=
|title=Foregen
|journal=
|volume=
|issue=
|pages=
|url=http://www.foregen.org/blog/?p=84
|quote=
|pubmedID=
|pubmedCID=
|DOI=
|date=2010-09-21
|accessdate=2010-11-28
}}</ref>
The proposed method would involve placing the patient under general anaesthesia. The penile skin would be opened at the circumcision scar, while the scar tissue is surgically debrided. A biomedical solution would then be applied to both ends of the wound, causing the foreskin to regenerate with the DNA in the patient's own cells. A biodegradable scaffold would be used to offer support for the regenerating foreskin.<ref>{{REFjournal
|last=
|first=
|title=Clinical Regen Trial
|journal=
|volume=
|issue=
|pages=
|url=http://www.foregen.org/projects/
|quote=
|pubmedID=
|pubmedCID=
|DOI=
|date=2010-06-23
|accessdate=2010-06-23
}}</ref>
In 2018, Foregen announced the creation of a "decellularized extracellular matrix–based biomaterial scaffold" for the purpose of regenerating human foreskin.<ref>{{REFjournal
|last=Purpura
|first=V.
|last2=Bondioli
|first2=E.
|last3=Cunningham
|first3=E.J.
|etal=yes
|title=The development of a decellularized extracellular matrix–based biomaterial scaffold derived from human foreskin for the purpose of foreskin reconstruction in circumcised males
|journal=Journal of Tissue Engineering
|date=2018
|volume=9
|issue=
|pages=1-11
|url=https://journals.sagepub.com/doi/full/10.1177/2041731418812613
|quote=
|pubmedID=30622692
|pubmedCID=PMC6304708
|DOI=10.1177/2041731418812613
|accessdate=2019-09-25
}}</ref>
Foreskin regeneration is only theoretical as of 2019. No foreskin has ever been regenerated. There is no assurance that foreskin regeneration will actually be successful.
Relocation section on foreskin regeneration.
As the shaft skin expands and gets longer the circumcision scar will travel down toward the tip and eventually turn under and be concealed inside the foreskin.
== Physical aspects ==
Books, websites and numerous articles have been published about foreskin restoration. See our compiled list of [[literature about foreskin restoration]].
== Regeneration of the foreskin ==
Recently there has been growing interest in regenerative medicine as a means to regenerate the human male foreskin. This option, unlike foreskin restoration, would result in a true human male foreskin being regrown.
In early 2010, [[Foregen]], a non-profit organization dedicated to funding a clinical trial for the purposes of regrowing the human male foreskin, had been founded. A clinical trial had been scheduled for late 2010, but there were insufficient donations to follow through.<ref>{{REFjournal
|last=
|first=
|title=Foregen
|journal=
|volume=
|issue=
|pages=
|url=http://www.foregen.org/blog/?p=84
|quote=
|pubmedID=
|pubmedCID=
|DOI=
|date=2010-09-21
|accessdate=2010-11-28
}}</ref>
The proposed method would involve placing the patient under general anaesthesia. The penile skin would be opened at the circumcision scar, while the scar tissue is surgically debrided. A biomedical solution would then be applied to both ends of the wound, causing the foreskin to regenerate with the DNA in the patient's own cells. A biodegradable scaffold would be used to offer support for the regenerating foreskin.<ref>{{REFjournal
|last=
|first=
|title=Clinical Regen Trial
|journal=
|volume=
|issue=
|pages=
|url=http://www.foregen.org/projects/
|quote=
|pubmedID=
|pubmedCID=
|DOI=
|date=2010-06-23
|accessdate=2010-06-23
}}</ref>
In 2018, Foregen announced the creation of a "decellularized extracellular matrix–based biomaterial scaffold" for the purpose of regenerating human foreskin.<ref>{{REFjournal
|last=Purpura
|first=V.
|last2=Bondioli
|first2=E.
|last3=Cunningham
|first3=E.J.
|etal=yes
|title=The development of a decellularized extracellular matrix–based biomaterial scaffold derived from human foreskin for the purpose of foreskin reconstruction in circumcised males
|journal=Journal of Tissue Engineering
|date=2018
|volume=9
|issue=
|pages=1-11
|url=https://journals.sagepub.com/doi/full/10.1177/2041731418812613
|quote=
|pubmedID=30622692
|pubmedCID=PMC6304708
|DOI=10.1177/2041731418812613
|accessdate=2019-09-25
}}</ref>
Foreskin regeneration is only theoretical as of 2020. No foreskin has ever been regenerated. There is no assurance that foreskin regeneration would actually be successful if attempted.
{{SEEALSO}}