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The '''preputial mucosa''' of the [[penis]] is the epithelium of the inside of the prepuce, or [[foreskin]]. To differentiate it from the cutaneous [[skin]] of the outside of the [[Foreskin|prepuce]], it is sometimes referred to as the '''inner mucosa'''. It starts at the mucocutaneous junction at the tip of the [[Foreskin|prepuce]] and continues to the coronal sulcus (groove behind the [[glans penis]]), where it meets the epithelium of the glans and penile shaft.<ref name="cold-taylor1999">{{ColdCJ TaylorJR 1999}}</ref> The preputial mucosa is devoid of hair, as is the cutaneous surface.<ref name="taylor1996">{{TaylorJR LockwoodAP TaylorAJ 1996}}</ref> The preputial mucosa is richly endowed with Meissner's corpuscles.<ref name="garcía-mesa2021">{{REFjournal |last=García-Mesa |first=Yolanda |init= |author-link= |last2=García-Piqueras |first2=Jorge |init2= |author2-link= |last3=Cobo |first3=Ramón |init3= |author3-link= |last4=Martín-Cruces |first4=José |init4= |author4-link= |last5=Suazo |first5=Iván |init5= |author5-link= |last6=García-Suárez |first6=Olivia |init6= |author6-link= |last7=Feito |first7=Jorge |init7= |author7-link= |last8= |first8=Vega |init8=José A. |author8-link= |etal=no |title=Sensory innervation of the human male prepuce: Meissner's corpuscles predominate |trans-title= |language= |journal=Journal of Anatomy |location= |date=2021-10 |volume=239 |issue=4 |article= |page= |pages=892-902 |url=https://onlinelibrary.wiley.com/doi/full/10.1111/joa.13481 |archived= |quote= |pubmedID=34120333 |pubmedCID=8450466 |DOI=10.1111/joa.13481 |accessdate=2022-03-18}}</ref>
Fleiss et al. (1998) report the inner [[mucosa]] contains apocrine glands, which secrete cathepsin B, lysozyme, chymotrypsin, neutrophil elastase, and hormones such as androsterone. The first four substances have protective immunological functions.<ref name="fleiss-hodges-vanhowe1998">{{FleissP HodgesF VanHoweRS 1998}}</ref>