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Foreskin

115 bytes removed, 11:28, 19 October 2019
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|last2=Taylor
|first2=J.R.
|author2-link=John R. Taylor
|title=The prepuce
|trans-title=
|language=
|journal=BJU Int
|date=1999-01-01
}}</ref>
Purpura ''et al.''. (2018) describe the foreskin as follows:<blockquote>{{Citation" |Text=Few parts of the human anatomy can compare to the incredibly multifaceted nature of the human foreskin. At times dismissed as “just skin,” the adult foreskin is, in fact, a highly vascularized and densely innervated bilayer tissue, with a surface area of up to 90 cm, and potentially larger. On average, the foreskin accounts for 51% of the total length of the penile shaft skin and serves a multitude of functions. The tissue is highly dynamic and biomechanically functions like a roller bearing; during intercourse, the foreskin “unfolds” and glides as abrasive friction is reduced and lubricating fluids are retained. The sensitive foreskin is considered to be the primary erogenous zone of the male [[penis]] and is divided into four subsections: inner mucosa, ridged band, frenulum, and outer foreskin; each section contributes to a vast spectrum of sensory pleasure through the gliding action of the foreskin, which mechanically stretches and stimulates the densely packed corpuscular receptors. Specialized immunological properties should be noted by the presence of Langerhans cells and other lytic materials, which defend against common microbes, and there is robust evidence supporting HIV protection. The [[glans penis| glans]] and inner mucosa are physically protected against external irritation and contaminants while maintaining a healthy, moist surface. The foreskin is also immensely vascularized and acts as a conduit for essential blood vessels within the penis, such as supplying the glans via the frenular artery." |Author=Purpura ''et al.'' |ref=<ref>{{REFjournal
|last=Purpura
|first=V.
|DOI=10.1177/2041731418812613
|accessdate=2019-09-25
}}</ref></blockquote>}}
== Structure ==
|last=Taylor
|first=J.R.
|author-link=John R. Taylor
|last2=Lockwood
|first2=A.P.
|first3=A.J.
|title=The prepuce: specialized mucosa of the penis and its loss to circumcision
|trans-title=
|language=
|journal=Brit J Urol
|date=1996
|first2=S.
|title=Human prepuce: some aspects of structure and function
|trans-title=
|language=
|journal=Indian J Surg
|date=1980
=== Protective functions ===
The foreskin provides physical protection to the glans penis and inner mucosa, protecting the mucosal tissue from pathogens, pollutants, friction, injury, and drying out.. The foreskin protects the glans penis and meatus from abrasion and irritation from ammoniacal diapers.<ref name="gairdner1949">{{REFjournal
|last=Gairdner
|first=D.
}}</ref>
Fleiss ''et al.''. noted the presence of Langerhans cells in the prepuce.<ref name="fleiss-hodges-vanhowe1998"/> De Witte ''et al''. (2007) have discovered that Langerhans cells produce Langerin, which is a "natural barrier to HIV infection".<ref>{{REFjournal
|last=de Witte
|first=Lot
Lakshamanan & Prakash (1980) report the "prepuce covers the glans completely and snugly like a hosiered material and continues to do so through the entire span of life of the male", which they explain as being caused by the smooth muscle fibers within the prepuce. The prepuce is free to glide back and forth. When it does, it must stretch to go over the glans penis.<ref name="lakshmanan-prakash1980" />
Taylor ''et al.''. (1996) carried out a histological study of the foreskin. (Histology is the microscopic examination of cells and tissues.) Taylor et al. found an area of rete ridges just inside the tip of the foreskin that he called the [[ridged band]]. The ridges were found to have nerve endings at the top of the ridges. They report that the ridged band area moves to the shaft of the penis when the penis becomes erect where the nerves are subject to stimulation. They stated:
<blockquote>
The prepuce provides a large and important platform for several nerves and nerve endings. The innervation of the outer skin of the prepuce is impressive; its sensitivity to light touch and pain are similar to that of the skin of the penis as a whole.
</blockquote>
Sorrells ''et al.''. (2007) conducted a fine-touch study of the penis of both circumcised and intact men. Sorrells ''et al''. concluded:
<blockquote>
In conclusion, circumcision removes the most sensitive parts of the penis and decreases the fine-touch pressure sensitivity of glans penis. The most sensitive regions in the uncircumcised penis are those parts ablated by circumcision. When compared to the most sensitive area of the circumcised penis, several locations on the uncircumcised penis (the rim of the preputial orifice, dorsal and ventral, the frenulum near the ridged band, and the frenulum at the muco-cutaneous junction) that are missing from the circumcised penis were significantly more sensitive.<ref>{{REFjournal
|last=SorrelsSorrells |first=MLM.L.
|author-link=
|last2=Synder
|first2=JLJ.L.
|author2-link=
|last3=Reiss
|first3=MDM.D.
|author3-link=
|last4=Eden
|first4=C.
|author4-link=
|last5=Milos
|first5=MFM.F. |author5-link=Marilyn Fayre Milos
|last6=Wilcox
|first6=nN.
|author6-link=
|last7=Van Howe
|first7=RSR.S.
|author7-link=
|last8=
|first8=
|author8-link=
|last9=
|first9=
|author9-link=
|etal=no
|title=Fine-touch pressure thresholds in the adult penis
|trans-title=
|language=
|journal=BJU Int
|date=2007-04
{{SEEALSO}}
 
* [[Retraction of the foreskin]]
 
* [[Ridged band]]
==External links=={{LINKS}}
* {{REFweb
|url=https://www.doctorsopposingcircumcision.org/for-professionals/the-prepuce/
|title=The prepuce
|trans-title=
|language=
|last=
|first=
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