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}}</ref>
Fleiss ''et al.'' noted the presence of [[Langerhans cells ]] in the prepuce.<ref name="fleiss-hodges-vanhowe1998"/> De Witte ''et al''. (2007) have discovered that Langerhans cells produce ''Langerin'', which is a "natural barrier to HIV infection".<ref>{{REFjournal
|last=de Witte
|first=Lot