Langerhans cells: Difference between revisions
WikiModEn2 (talk | contribs) m Improve footnote |
WikiModEn2 (talk | contribs) m Improve footnotes; Revise text to better reflect former and current views. |
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|date=1868 | |date=1868 | ||
|accessdate=2010-10-20 | |accessdate=2010-10-20 | ||
}}</ref> Because of their dendritic nature, he mistakenly identified the cells as part of the nervous system.<ref | }}</ref> Because of their dendritic nature, he mistakenly identified the cells as part of the nervous system.<ref>{{REFweb | ||
|url=https://omim.org/entry/604856 | |||
|title=Langerhans cell histiocytosis | |||
|trans-title= | |||
|language= | |||
|last=McKusick | |||
|first=Victor A | |||
|author-link= | |||
|publisher= | |||
|website=OMIM | |||
|date=2000-04-20 | |||
|accessdate=2019-10-20 | |||
|format= | |||
|quote= | |||
}}</ref> | |||
==Function== | ==Function== | ||
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|issue=13 | |issue=13 | ||
|pages=3119-31 | |pages=3119-31 | ||
|url= | |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150992/ | ||
|quote= | |quote= | ||
|pubmedID=18086861 | |pubmedID=18086861 | ||
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=== HIV === | === HIV === | ||
====Former hypothesis==== | |||
Langerhans cells | Kawamura ''et al''. (2005) suggested Langerhans cells may be initial cellular targets in the sexual transmission of HIV,<ref>{{REFjournal | ||
|last=Kawamura | |last=Kawamura | ||
|first=Tatsuyoshi | |first=Tatsuyoshi | ||
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|issue=3 | |issue=3 | ||
|pages=147-55 | |pages=147-55 | ||
|url= | |url=https://www.sciencedirect.com/science/article/pii/S0923181105002586 | ||
|quote= | |quote= | ||
|pubmedID=16226431 | |pubmedID=16226431 | ||
|pubmedCID= | |pubmedCID= | ||
|DOI=10.1016/j.jdermsci.2005.08.009 | |DOI=10.1016/j.jdermsci.2005.08.009 | ||
|date= | |date=2005-12 | ||
|accessdate= | |accessdate=https://www.sciencedirect.com/science/article/pii/S0923181105002586 | ||
}}</ref> and as a target, reservoir, and vector of dissemination.<ref>{{REFjournal | }}</ref> and as a target, reservoir, and vector of dissemination.<ref>{{REFjournal | ||
|last=Dezutter-Dambuyant | |last=Dezutter-Dambuyant | ||
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|DOI= | |DOI= | ||
|date=December 1995 | |date=December 1995 | ||
|accessdate= | |accessdate=2019-10-20 | ||
|language=French | |language=French | ||
}}</ref> | }}</ref> | ||
Langerhans cells have been observed in foreskin, vaginal, and oral mucosa of humans; the lower concentrations in oral mucosa suggest that it is not a likely source of [[HIV]] infection relative to foreskin and vaginal mucosa.<ref name="pmid7558138">{{REFjournal | Hussain & Lehner (2005) observed Langerhans cells have been observed in foreskin, vaginal, and oral mucosa of humans; the lower concentrations in oral mucosa suggest that it is not a likely source of [[HIV]] infection relative to foreskin and vaginal mucosa.<ref name="pmid7558138">{{REFjournal | ||
|last=Hussain | |last=Hussain | ||
|first=L.A. | |first=L.A. | ||
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}}</ref> | }}</ref> | ||
On March 4, 2007 the online Nature Medicine magazine published the letter "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells."<ref>{{REFjournal | ====Present view==== | ||
On March 4, 2007 the online ''Nature Medicine'' magazine published the letter "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells."<ref>{{REFjournal | |||
|last=De Witte | |last=De Witte | ||
|first=Lot | |first=Lot | ||