Difference between revisions of "HIV trials in Africa"

From IntactiWiki
Jump to navigation Jump to search
m (using Template:FrischM SimonsenJ 2021)
(Add text and citation.)
 
(3 intermediate revisions by 2 users not shown)
Line 1: Line 1:
−
In 2005 and 2007, randomized controlled trials (RCTs) were carried out in Africa in an attempt to prove a hypothesis of certain [[circumcision advocate|circumcision promoters]] despite the known [[Immunological and protective function of the foreskin| immunological functions]] of the [[foreskin]], to link HIV infection to lack of [[circumcision]].
+
In 2005 and 2007, randomized controlled trials (RCTs) were carried out in Africa in an attempt to prove a hypothesis of certain [[circumcision advocate|circumcision promoters]] despite the known [[Immunological and protective function of the foreskin| immunological functions]] of the [[foreskin]], to link [[HIV]] infection to lack of [[circumcision]].
  
 
These trials were carried out in
 
These trials were carried out in
−
* South Africa:
+
* [[South Africa]]:
 
: {{RCT Auvert et al 2005}}
 
: {{RCT Auvert et al 2005}}
 
* Kenya:
 
* Kenya:
Line 10: Line 10:
  
 
The 2007 RCTs in Kenya and Uganda were funded by NIAID director [[Anthony Fauci]].
 
The 2007 RCTs in Kenya and Uganda were funded by NIAID director [[Anthony Fauci]].
 +
 +
[[PEPFAR]] (2025) has scrapped its ineffective and harmful "voluntary male  medical circumcision" (VMMC) program after 15 years and at least 27,000,000 harmful and useless [[foreskin]] amputations.<ref name="gwarisa2025">{{REFnews
 +
|title=New PEPFAR Waiver Scraps Voluntary Medical Male Circumcision Program
 +
|url=https://healthtimes.co.zw/2025/02/07/new-pepfar-waiver-scraps-voluntary-medical-male-circumcision-program/
 +
|last=Gwarisa
 +
|first=Michael
 +
|init=
 +
|author-link=
 +
|publisher=Healthtimes
 +
|website=
 +
|date=2025-02-07
 +
|accessdate=2025-02-16
 +
|format=
 +
|quote=
 +
}}</ref> The [[United States]] government will no longer pay for harmful circumcisions in Africa.
  
 
== 60% HIV protection myth ==
 
== 60% HIV protection myth ==
Line 104: Line 119:
 
  |accessdate=2022-01-07
 
  |accessdate=2022-01-07
 
}}</ref><ref name="frisch2021">{{FrischM SimonsenJ 2021}}</ref>
 
}}</ref><ref name="frisch2021">{{FrischM SimonsenJ 2021}}</ref>
−
 
+
{{SEEALSO}}
 +
* [[HIV]]
 +
* [[South Africa]]
 
{{REF}}
 
{{REF}}
  
Line 114: Line 131:
 
[[Category:South Africa]]
 
[[Category:South Africa]]
 
[[Category:Uganda]]
 
[[Category:Uganda]]
 +
 +
[[de:HIV-Studien in Afrika]]

Latest revision as of 15:15, 16 February 2025

In 2005 and 2007, randomized controlled trials (RCTs) were carried out in Africa in an attempt to prove a hypothesis of certain circumcision promoters despite the known immunological functions of the foreskin, to link HIV infection to lack of circumcision.

These trials were carried out in

REFjournal Auvert B, Taljaard D, Lagarde E, Sobngwi-Tambekou J, Sitta R, Puren A. Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial. PLoS Med. 25 October 2005; 2(11): e298. Retrieved 31 December 2021.
  • Kenya:
REFjournal Bailey RC, Moses S, Parker CB, et al. Male circumcision for HIV prevention in young men in Kisumu, Kenya: A randomised controlled trial. Lancet. 24 February 2007; 369(9562): 643–56. PMID. DOI. Retrieved 31 December 2021.
  • Uganda:
REFjournal Gray RH, Kigozi G, Serwadda D, et al. Male circumcision for HIV prevention in men in Rakai, Uganda: A randomised trial. Lancet. 24 February 2007; 369(9562): 657-66. PMID. DOI. Retrieved 31 December 2021.

The 2007 RCTs in Kenya and Uganda were funded by NIAID director Anthony Fauci.

PEPFAR (2025) has scrapped its ineffective and harmful "voluntary male medical circumcision" (VMMC) program after 15 years and at least 27,000,000 harmful and useless foreskin amputations.[1] The United States government will no longer pay for harmful circumcisions in Africa.

60% HIV protection myth

These RCTs are the cause of the false and long since disproved claim that circumcision would offer a 60% better protection against HIV than uncircumcised people have.

Refutation

Green et al. (2008), in a preliminary report, published a long list of methodological issues with the RCTs.[2]

Boyle & Hill (2011) studied their reports and found disabling methodological and statistical errors that invalidated their purported findings.[3]

Van Howe & Boyle (2018) further elaborated on these findings and suggested possible coordination between the RCTs and hinted at the possibility of fraud.[4]

Two massive populalation studies found no evidence of a protective effect from circumcision.[5][6]

See also

References

  1. Jump up ↑ REFnews Gwarisa, Michael (7 February 2025)."New PEPFAR Waiver Scraps Voluntary Medical Male Circumcision Program", Healthtimes. Retrieved 16 February 2025.
  2. Jump up ↑ REFjournal Green LW, McAllister RS, Peterson KW, Travis JR. Male circumcision is not the HIV ‘vaccine’ we have been waiting for!. Future HIV Therapy. 2008; 2(3): 193-9. DOI. Retrieved 29 November 2021.
  3. Jump up ↑ REFjournal Boyle GJ, Hill G. Sub-Saharan African randomised clinical trials into male circumcision and HIV transmission: Methodological, ethical and legal concerns PDF. Thompson Reuter. December 2011; 19(2): 316-34. PMID. Retrieved 30 December 2020.
  4. Jump up ↑ REFjournal Van Howe RS, Boyle GJ. Meta-analysis of HIV-acquisition studies incomplete and unstable. BJU Int. 31 October 2018; Retrieved 24 November 2021.
    Quote: Given the effectiveness of condoms, the lack of consistent findings on national levels, the methodologically flawed RCTs, the lack of translational research, and the impressive potential uptake and effectiveness of pre-exposure prophylaxis, circumcision as an intervention to prevent HIV infection should be treated with greater scepticism.
  5. Jump up ↑ REFjournal Mayan M, Hamilton RJ, Juurlink DN, Austin PC, Jarvi KA. Circumcision and Risk of HIV Among Males From Ontario, Canada. J Urol. 23 September 2021; PMID. DOI. Retrieved 7 January 2022.
    Quote: We found that circumcision was not independently associated with the risk of acquiring HIV among men from Ontario, Canada.
  6. Jump up ↑ REFjournal Frisch M, Simonsen J. Non-therapeutic male circumcision in infancy or childhood and risk of human immunodeficiency virus and other sexually transmitted infections: national cohort study in Denmark. Eur J Epidemiol. 26 September 2021; 37: 251–9. PMID. DOI. Retrieved 16 January 2022.
Retrieved from "https://en.intactiwiki.org/w/index.php?title=HIV_trials_in_Africa&oldid=40805"