Foreskin regeneration

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Foreskin regeneration is the term applied to the creation of a foreskin by the application of tissue engineering and regenerative medicine to regeneration of the lost foreskin for those men who have lost their foreskin to circumcision.

Foreskin regeneration remains experimental and under development in the Spring of 2024 as no foreskin has yet been regenerated.

Foreskin regeneration would use a different process from foreskin restoration as has been practiced since ancient times.

Foreskin regeneration has been promoted by Vincenzo Aiello of Rome, Italy, who has created Foregen, an Italian charitable organization, in 2010, to advance the development of foreskin regeneration.

Progress reports

  • Foregen announced in 2018 that it had completed a decellularized extracellular matrix–based biomaterial scaffold, which is to be used in foreskin regeneration.[1]
  • Aiello (April 2023) announced the successful completion of animal trials using sheep.
  • Novatna et al. (2023) compared two different methods of decellularization techniques of human foreskin and found that both methods are satisfactory.[2]

Video

Progress update April 2023 (by Mr. Aiello)

Load video
YouTube

Economics

Brendon Marotta estimates that the market for foreskin regeneration may be more than $200 billion.[3]

See also

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References

  1. ↑ REFjournal {{#if:Purpura|{{#if:|{{#if:V|[[|Purpura V]]|[[|Purpura{{#if:Valeria|, Valeria|}}]]}}|{{#if:V|Purpura V|Purpura{{#if:Valeria|, Valeria|}}|}}|}}|}}{{#if:Bondioli|{{#if:|{{#if:E|, [[|Bondioli E]]|, [[|Bondioli{{#if:Elena|, Elena|}}]]}}|{{#if:E|, Bondioli E|, Bondioli{{#if:Elena|, Elena|}}|}}|}}|}}{{#if:Cunningham|{{#if:|{{#if:EC|, [[|Cunningham EC]]|, [[|Cunningham{{#if:Eric J.|, Eric J.|}}]]}}|{{#if:EC|, Cunningham EC|, Cunningham{{#if:Eric J.|, Eric J.|}}|}}|}}|}}{{#if:|{{#if:|{{#if:|, [[{{{author4-link}}}|{{{last4}}} {{{init4}}}]]|, [[{{{author4-link}}}|{{{last4}}}{{#if:|, {{{first4}}}|}}]]}}|{{#if:|, {{{last4}}} {{{init4}}}|, {{{last4}}}{{#if:|, {{{first4}}}|}}|}}|}}|}}{{#if:|{{#if:|{{#if:|, [[{{{author5-link}}}|{{{last5}}} {{{init5}}}]]|, [[{{{author5-link}}}|{{{last5}}}{{#if:|, {{{first5}}}|}}]]}}|{{#if:|, {{{last5}}} {{{init5}}}|, {{{last5}}}{{#if:|, {{{first5}}}|}}|}}|}}|}}{{#if:|{{#if:|{{#if:|, [[{{{author6-link}}}|{{{last6}}} {{{init6}}}]]|, [[{{{author6-link}}}|{{{last6}}}{{#if:|, {{{first6}}}|}}]]}}|{{#if:|, {{{last6}}} {{{init6}}}|, {{{last6}}}{{#if:|, {{{first6}}}|}}|}}|}}|}}{{#if:|{{#if:|{{#if:|, [[{{{author7-link}}}|{{{last7}}} {{{init7}}}]]|, [[{{{author7-link}}}|{{{last7}}}{{#if:|, {{{first7}}}|}}]]}}|{{#if:|, {{{last7}}} {{{init7}}}|, {{{last7}}}{{#if:|, {{{first7}}}|}}|}}|}}|}}{{#if:|{{#if:|{{#if:|, [[{{{author8-link}}}|{{{last8}}} {{{init8}}}]]|, [[{{{author8-link}}}|{{{last8}}}{{#if:|, {{{first8}}}|}}]]}}|{{#if:|, {{{last8}}} {{{init8}}}|, {{{last8}}}{{#if:|, {{{first8}}}|}}|}}|}}|}}{{#if:|{{#if:|{{#if:|, [[{{{author9-link}}}|{{{last9}}} {{{init9}}}]]|, [[{{{author9-link}}}|{{{last9}}}{{#if:|, {{{first9}}}|}}]]}}|{{#if:|, {{{last9}}} {{{init9}}}|, {{{last9}}}{{#if:|, {{{first9}}}|}}|}}|}}|}}{{#if:|; with {{{coauthors}}} [deprecated REFjournal parameter used: <coauthors> - please use <last2>, etc.]|}}{{#ifeq:yes|yes|, et al.|{{#if:Purpura|.|}}}}{{#if:| ({{{publisher}}})|}} {{#if:https://journals.sagepub.com/doi/full/10.1177/2041731418812613%7CThe development of a decellularized extracellular matrix–based biomaterial scaffold derived from human foreskin for the purpose of foreskin reconstruction in circumcised males{{#if:| PDF|}}{{#ifeq:|yes| (archive URL)|}}|The development of a decellularized extracellular matrix–based biomaterial scaffold derived from human foreskin for the purpose of foreskin reconstruction in circumcised males}}{{#if:| [{{{trans-title}}}]{{#if:| ({{{language}}})|}}|}}{{#if:J Tissue Eng|. J Tissue Eng{{#if:| ()}}.|}}{{#if:2018-12-22| {{#switch:{{#invoke:String|len|s=2018-12-22}} |0 |1 |2 = |3 |4 |5 = {{#time:Y|2018-12-22 }} |6 |7 |8 = {{#time:F Y|2018-12-22 }} |9 |10 = {{#time:j F Y|2018-12-22 }} |#default = error }}{{#if:| ({{{season}}})|}}; | }}{{#if:| '|}}{{#if:|()|}}{{#if: |{{#if:|: [{{{article}}}]|}}{{#if:|: {{{page}}}|}}{{#if:|: |}}.|}}{{#if:30622692| PMID.|}}{{#if:6304708| PMC.|}}{{#if:10.1177/2041731418812613| DOI.|}}{{#if:| DOI.|}}{{#if:2024-03-16| Retrieved {{#switch:{{#invoke:String|len|s=2024-03-16}} |0 |1 |2 = |3 |4 |5 = {{#time:Y|2024-03-16 }} |6 |7 |8 = {{#time:F Y|2024-03-16 }} |9 |10 = {{#time:j F Y|2024-03-16 }} |#default = error }}.|}}{{#if:|
    Quote: |}}
  2. ↑ REFjournal {{#if:Novatna|{{#if:|{{#if:O|[[|Novatna O]]|[[|Novatna{{#if:|, |}}]]}}|{{#if:O|Novatna O|Novatna{{#if:|, |}}|}}|}}|}}{{#if:Varchulova Novakova,|{{#if:|{{#if:V|, [[|Varchulova Novakova, V]]|, [[|Varchulova Novakova,{{#if:|, |}}]]}}|{{#if:V|, Varchulova Novakova, V|, Varchulova Novakova,{{#if:|, |}}|}}|}}|}}{{#if:Galfiova|{{#if:|{{#if:P|, [[|Galfiova P]]|, [[|Galfiova{{#if:|, |}}]]}}|{{#if:P|, Galfiova P|, Galfiova{{#if:|, |}}|}}|}}|}}{{#if:Lorencova|{{#if:|{{#if:P|, [[|Lorencova P]]|, [[|Lorencova{{#if:|, |}}]]}}|{{#if:P|, Lorencova P|, Lorencova{{#if:|, |}}|}}|}}|}}{{#if:Klein|{{#if:|{{#if:M|, [[|Klein M]]|, [[|Klein{{#if:|, |}}]]}}|{{#if:M|, Klein M|, Klein{{#if:|, |}}|}}|}}|}}{{#if:Žiaran|{{#if:|{{#if:A|, [[|Žiaran A]]|, [[|Žiaran{{#if:|, |}}]]}}|{{#if:A|, Žiaran A|, Žiaran{{#if:|, |}}|}}|}}|}}{{#if:Kuniakova|{{#if:|{{#if:M|, [[|Kuniakova M]]|, [[|Kuniakova{{#if:|, |}}]]}}|{{#if:M|, Kuniakova M|, Kuniakova{{#if:|, |}}|}}|}}|}}{{#if:|{{#if:|{{#if:|, [[{{{author8-link}}}|{{{last8}}} {{{init8}}}]]|, [[{{{author8-link}}}|{{{last8}}}{{#if:|, {{{first8}}}|}}]]}}|{{#if:|, {{{last8}}} {{{init8}}}|, {{{last8}}}{{#if:|, {{{first8}}}|}}|}}|}}|}}{{#if:|{{#if:|{{#if:|, [[{{{author9-link}}}|{{{last9}}} {{{init9}}}]]|, [[{{{author9-link}}}|{{{last9}}}{{#if:|, {{{first9}}}|}}]]}}|{{#if:|, {{{last9}}} {{{init9}}}|, {{{last9}}}{{#if:|, {{{first9}}}|}}|}}|}}|}}{{#if:|; with {{{coauthors}}} [deprecated REFjournal parameter used: <coauthors> - please use <last2>, etc.]|}}{{#ifeq:no|yes|, et al.|{{#if:Novatna|.|}}}}{{#if:| ({{{publisher}}})|}} {{#if:https://www.biomed.cas.cz/physiolres/pdf/2023/72_S287.pdf%7CDecellularization techniques of human foreskin for tissue engineering application{{#if:| Error creating thumbnail: |}}{{#ifeq:|yes| (archive URL)|}}|Decellularization techniques of human foreskin for tissue engineering application}}{{#if:| []{{#if:| ()|}}|}}{{#if:Physiol Res|. Physiol Res{{#if:| ()}}.|}}{{#if:2023-10-27| {{#switch:{{#invoke:String|len|s=2023-10-27}} |0 |1 |2 = |3 |4 |5 = {{#time:Y|2023-10-27 }} |6 |7 |8 = {{#time:F Y|2023-10-27 }} |9 |10 = {{#time:j F Y|2023-10-27 }} |#default = error }}{{#if:| ({{{season}}})|}}; | }}{{#if:72| 72|}}{{#if:S3|(S3)|}}{{#if: S287-S297|{{#if:|: []|}}{{#if:|: |}}{{#if:S287-S297|: S287-S297|}}.|}}{{#if:37888972| PMID.|}}{{#if:10669949| PMC.|}}{{#if:10.33549/physiolres.935185| DOI.|}}{{#if:| DOI.|}}{{#if:2023-03-16| Retrieved {{#switch:{{#invoke:String|len|s=2023-03-16}} |0 |1 |2 = |3 |4 |5 = {{#time:Y|2023-03-16 }} |6 |7 |8 = {{#time:F Y|2023-03-16 }} |9 |10 = {{#time:j F Y|2023-03-16 }} |#default = error }}.|}}{{#if:|
    Quote: |}}
  3. ↑ REFweb {{#if:Marotta|{{#if:Brendon Marotta|{{#if:|Marotta |Marotta{{#if:Brendon|, Brendon|}}}}|{{#if:|Marotta |Marotta{{#if:Brendon|, Brendon|}}|}}|}}|}}{{#if:2023-06-28|{{#if:Marotta| ({{#switch:{{#invoke:String|len|s=2023-06-28}} |0 |1 |2 = |3 |4 |5 = {{#time:Y|2023-06-28 }} |6 |7 |8 = {{#time:F Y|2023-06-28 }} |9 |10 = {{#time:j F Y|2023-06-28 }} |#default = error }}). |({{#switch:{{#invoke:String|len|s=2023-06-28}} |0 |1 |2 = |3 |4 |5 = {{#time:Y|2023-06-28 }} |6 |7 |8 = {{#time:F Y|2023-06-28 }} |9 |10 = {{#time:j F Y|2023-06-28 }} |#default = error }}). }}|{{#if:Marotta|. |}}}}{{#if:https://www.hegemonmedia.com/p/survey-data-shows-the-foreskin-regeneration%7C{{#if:Survey Data Shows The Foreskin Regeneration Market Is Over 200 Billion Dollars|Survey Data Shows The Foreskin Regeneration Market Is Over 200 Billion Dollars{{#if:| Error creating thumbnail: |}}|[<title> parameter missing!]}}|[<url> parameter missing!]{{#if:Survey Data Shows The Foreskin Regeneration Market Is Over 200 Billion Dollars|Survey Data Shows The Foreskin Regeneration Market Is Over 200 Billion Dollars|[<title> parameter missing!]}}{{#if:| (PDF)|}}}}{{#ifeq:|yes| (archive URL)|}}{{#if:| [{{{trans-title}}}]{{#if:| ({{{language}}})|}}|}}{{#if:|, {{{website}}}|}}{{#if: |, {{{work}}} [deprecated REFweb parameter used: use <website> instead]|}}{{#if:Hegemon Media|, Hegemon Media|}}{{#if:2024-03-16|. Retrieved {{#switch:{{#invoke:String|len|s=2024-03-16}} |0 |1 |2 = |3 |4 |5 = {{#time:Y|2024-03-16 }} |6 |7 |8 = {{#time:F Y|2024-03-16 }} |9 |10 = {{#time:j F Y|2024-03-16 }} |#default = error }}|}}.{{#if:|
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