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Foregen is a registered Italian charity. Foregen was founded by Sig. Vincenzo Aiello of Italy to promote and arrange a clinical trial that would use regenerative techniques to regrow the tissue removed at circumcision. Foregen's goal is to heal the physical loss of functional tissue that is inherent to circumcision. Foregen's principal office is at Via Campi Flegrei 59, 00141 Rome, Italy.


After dismissing many unsatisfactory proposals from research institutions, Foregen decided to conduct its own research and clinical trials. Foregen has applied regenerative techniques to animal foreskins and will continue research on adult human foreskins.

Foregen announced in 2018 that it had completed a decellularized extracellular matrix–based biomaterial scaffold, which is to be used in foreskin regeneration.[1]

Foregen announced in December 2021 that it is hoped that clinical trials would commence in April 2023.[2]

Regenerative medicine

Regenerative medical techniques now offer a greater possibility than ever to regrow human tissue, especially dermal tissue, lost in prior trauma. Regenerative medicine has been used to recreate vaginas of women with some congenital conditions[3]. Experiments have been performed to regenerate the penis of rabbits.[4] [5][6] Also progress has been made in penile transplants[7] [8] and phalloplasties[9]. However, regenerative medicine has not yet been applied to those who have been circumcised, but no longer wish to be.

For more information on the science behind Foregen, read: The science of regeneration


Foregen’s tasks are:

  • To experiment with animal tissue to obtain a viable method of foreskin regeneration
  • To apply the experience from animal experiments to regenerate human foreskins
  • To advance onto clinical trials once Foregen proves that regenerating human foreskin is possible

Foregen is a charity

Foregen™ was created in 2010 thanks to donor funds. Foregen operates in the United States and Europe. Its head office is in Rome, Italy, where it is a registered charity (Reg. No. 6482, Serie 1T, 2010). See original founding documents here. Foregen is also tax-exempt under section 501(c)(3) of the Internal Revenue Code and is headed by a board of charitable directors with participants and donors across both continents and beyond.

Foreget announced on 19 December 2021 that its cummulative donations had exceeded $1 million.


Message from Foregen's president, Vincenzo Aiello

HUFO - The Missing Piece

Foregen and the Science of Regeneration

Sheep Trials Part 1: Preparing the Sheep and Attaching ECMs

Consultation with Dr. Dan mon O'Dey

Vincenzo Aiello announces success of sheep trials

Progress reports

Forgen released the results of a survey on 9 January 2023 which reported that 21 percent of American circumcised men (more than 18 million) would consider undergoing a procedure to regenerate their foreskin.‍[10]

As of March 2024, Foregen has not yet regenerated a foreskin.

Social media

Foregen in the media

See also

External links


  1. REFjournal Purpura V, Bondioli E, Cunningham EC, et al. The development of a decellularized extracellular matrix–based biomaterial scaffold derived from human foreskin for the purpose of foreskin reconstruction in circumcised males. J Tissue Eng. 22 December 2018; PMID. PMC. DOI. Retrieved 9 February 2020.
  2. REFweb (December 2021). Human Clinical Trials Application Form. Retrieved 20 December 2021.
  3. REFnews Richardson, Karen (10 April 2014)."Laboratory-Grown Vaginas Implanted in Patients, Scientists Report", Wake Forest Baptist Medical Center. Retrieved 15 July 2015.
  4. REFnews Geggel, Laura (9 October 2014)."Scientists developing lab-grown penis for transplant", LiveScience, CBS News. Retrieved 15 July 2015.
  5. REFnews "Engineered Penile Erectile Tissue", Wake Forest School of Medicine. Retrieved 15 July 2015.
  6. REFnews Mohammadi, Dara (4 October 2014)."The lab-grown penis: approaching a medical milestone", The Guardian. Retrieved 15 July 2015.
  7. REFnews Smith, David (13 March 2015)."Man gets world's first successful penis transplant after botched circumcision", The Guardian. Retrieved 15 July 2015.
  8. REFnews Feltman, Rachel (12 June 2015)."Man who had world's first penis transplant to become a father", The Independent. Retrieved 15 July 2015.
  9. REFnews Ho, Vivian (22 April 2014)."Man may be 1st to father child with reconstructed penis", SFGate. Retrieved 15 July 2015.
  10. REFweb Serody, Matthew R. (9 January 2023). 5 Million Men? More Than Triple That: Over 18 Million American Men Would Consider Regenerating Their Foreskin., Foregen. Retrieved 11 January 2023.