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→Characteristics of longer foreskins: Add citation.
|DOI=10.1258/ijsa.2008.008106
|accessdate=2025-07-04
}}</ref> Fleiss, Hodges & Van Howe (1998) reported the presence of cathepsin B, lysosyme, chymotrypsin, neutrophil elastase, and cytokine in the sub-preputial moisture. <ref name="fleiss1998">{{FleissP HodgesF VanHoweRS 1998}}</ref> These substances have a destructive lytic effect on pathogens and make the preputial sac a trap for disease-causing organisms.
Men with the longest foreskins are able to glide the [[foreskin]] without exposing the [[glans penis]].