The preputial mucosa of the penis is the epithelium of the inside of the prepuce, or foreskin. To differentiate it from the cutaneous skin of the outside of the prepuce, it is sometimes referred to as the inner mucosa. It starts at the ridged band of the prepuce and continues to the coronal sulcus (groove behind the glans penis), where it meets the epithelium of the glans and penile shaft. The preputial mucosa is devoid of hair, as is the cutaneous surface.
Fleiss et al. (1998) report the inner mucosa contains apocrine glands, which secrete cathepsin B, lysozyme, chymotrypsin, neutrophil elastase, and hormones such as androsterone. The first four substances have protective immunological functions.
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