Difference between revisions of "Foregen"

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'''Foregen'''’s goal is to heal the physical detriment that that is inherent to circumcision.  
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[[Image:Foregen logo.png|right]]
  
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[[Image:Foregen logo.png]]
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'''Foregen''' is a registered Italian charity. Foregen was founded by Sig. [[Vincenzo Aiello]] of Italy to promote and arrange a clinical trial that would use regenerative techniques to regrow the tissue removed at circumcision. Foregen's goal is to heal the physical loss of functional tissue that is inherent to [[circumcision]]. Foregen's principal office is at Via Campi Flegrei 59, 00141 Rome, Italy.
 +
==History==
 +
After dismissing many unsatisfactory proposals from research institutions, Foregen decided to conduct its own research and clinical trials. Foregen has applied regenerative techniques to animal foreskins and will continue research on adult human foreskins.
  
−
Regenerative medical techniques now offer a greater possibility than ever to regrow human tissue, especially dermal tissue, lost in prior trauma. Regenerative medicine has been used to recreate vaginas of women with some congenital conditions<ref>{{REFnews
+
Foregen announced in 2018 that it had completed a decellularized extracellular matrix–based biomaterial scaffold, which is to be used in foreskin regeneration.<ref>{{REFjournal
−
  | last=Richardson
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|last=Purpura
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  | first=Karen
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|first=Valeria
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| coauthors=
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|init=V
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  | url=http://www.wakehealth.edu/News-Releases/2014/Laboratory-Grown_Vaginas_Implanted_in_Patients,_Scientists_Report.htm
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|author-link=
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  | title=Laboratory-Grown Vaginas Implanted in Patients, Scientists Report
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|last2=Bondioli
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  | publisher=Wake Forest Baptist Medical Center
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|first2=Elena
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  | work=
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|init2=E
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  | quote=
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|author2-link=
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  | date=2014-04-10
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|last3=Cunningham
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  | accessdate=2015-07-15
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|first3=Eric J.
 +
|init3=EC
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|author3-link=
 +
|etal=yes
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|title=The development of a decellularized extracellular matrix–based biomaterial scaffold derived from human foreskin for the purpose of foreskin reconstruction in circumcised males
 +
|journal=J Tissue Eng
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|location=
 +
|date=2018-12-22
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|volume=
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|issue=
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|pages=
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|url=https://journals.sagepub.com/doi/full/10.1177/2041731418812613
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|quote=
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|pubmedID=30622692
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|pubmedCID=6304708
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|DOI=10.1177/2041731418812613
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|accessdate=2020-02-09
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}}</ref>
 +
 
 +
Foregen announced in December 2021 that it is hoped that clinical trials would commence in April 2023.<ref>{{REFweb
 +
|url=https://www.foregen.org/clinical-trials
 +
|title=Human Clinical Trials Application Form
 +
|last=
 +
|first=
 +
|date=2021-12
 +
|accessdate=2021-12-20
 +
}}</ref>
 +
 
 +
==Regenerative medicine==
 +
Regenerative medical techniques now offer a greater possibility than ever to regrow human tissue, especially dermal tissue, lost in prior [[trauma]]. Regenerative medicine has been used to recreate vaginas of women with some congenital conditions<ref>{{REFnews
 +
  |last=Richardson
 +
  |first=Karen
 +
  |url=http://www.wakehealth.edu/News-Releases/2014/Laboratory-Grown_Vaginas_Implanted_in_Patients,_Scientists_Report.htm
 +
  |title=Laboratory-Grown Vaginas Implanted in Patients, Scientists Report
 +
  |publisher=Wake Forest Baptist Medical Center
 +
  |website=
 +
  |quote=
 +
  |date=2014-04-10
 +
  |accessdate=2015-07-15
 
}}</ref>. Experiments have been performed to regenerate the penis of rabbits.<ref>{{REFnews
 
}}</ref>. Experiments have been performed to regenerate the penis of rabbits.<ref>{{REFnews
−
  | last=Geggel
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  |last=Geggel
−
  | first=Laura
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  |first=Laura
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| coauthors=
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  |url=http://www.cbsnews.com/news/scientists-developing-lab-grown-penis-for-transplant/
−
  | url=http://www.cbsnews.com/news/scientists-developing-lab-grown-penis-for-transplant/
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  |title=Scientists developing lab-grown penis for transplant
−
  | title=Scientists developing lab-grown penis for transplant
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  |publisher=CBS News
−
  | publisher=CBS News
+
  |website=LiveScience
−
  | work=LiveScience
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  |quote=
−
  | quote=
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  |date=2014-10-09
−
  | date=2014-10-09
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  |accessdate=2015-07-15
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  | accessdate=2015-07-15
 
 
}}</ref> <ref>{{REFnews
 
}}</ref> <ref>{{REFnews
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  | last=
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  |last=
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  | first=
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  |first=
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| coauthors=
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  |url=http://www.wakehealth.edu/Research/Urology/Regenerative-Medicine/Engineered-Penile-Erectile-Tissue.htm
−
  | url=http://www.wakehealth.edu/Research/Urology/Regenerative-Medicine/Engineered-Penile-Erectile-Tissue.htm
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  |title=Engineered Penile Erectile Tissue
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  | title=Engineered Penile Erectile Tissue
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  |publisher=Wake Forest School of Medicine
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  | publisher=Wake Forest School of Medicine
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  |quote=
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| work=
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  |date=
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  | quote=
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  |accessdate=2015-07-15
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  | date=
 
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  | accessdate=2015-07-15
 
 
}}</ref><ref>{{REFnews
 
}}</ref><ref>{{REFnews
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  | last=Mohammadi
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  |last=Mohammadi
−
  | first=Dara
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  |first=Dara
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| coauthors=
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  |url=http://www.theguardian.com/education/2014/oct/04/penis-transplants-anthony-atala-interview
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  | url=http://www.theguardian.com/education/2014/oct/04/penis-transplants-anthony-atala-interview
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  |title=The lab-grown penis: approaching a medical milestone
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  | title=The lab-grown penis: approaching a medical milestone
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  |publisher=The Guardian
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  | publisher=The Guardian
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  |quote=
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| work=
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  |date=2014-10-04
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  | quote=
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  |accessdate=2015-07-15
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  | date=2014-10-04
 
−
  | accessdate=2015-07-15
 
 
}}</ref> Also progress has been made in penile transplants<ref>{{REFnews
 
}}</ref> Also progress has been made in penile transplants<ref>{{REFnews
−
  | last=Smith
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  |last=Smith
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  | first=David
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  |first=David
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| coauthors=
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  |url=http://www.theguardian.com/world/2015/mar/13/south-africa-man-penis-transplant
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  | url=http://www.theguardian.com/world/2015/mar/13/south-africa-man-penis-transplant
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  |title=Man gets world's first successful penis transplant after botched circumcision
−
  | title=Man gets world's first successful penis transplant after botched circumcision
+
  |publisher=The Guardian
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  | publisher=The Guardian
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  |quote=
−
| work=
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  |date=2015-03-13
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  | quote=
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  |accessdate=2015-07-15
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  | date=2015-03-13
 
−
  | accessdate=2015-07-15
 
 
}}</ref> <ref>{{REFnews
 
}}</ref> <ref>{{REFnews
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  | last=Feltman
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  |last=Feltman
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  | first=Rachel
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  |first=Rachel
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| coauthors=
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  |url=http://www.independent.co.uk/life-style/health-and-families/health-news/man-who-had-worlds-first-penis-transplant-to-become-a-father-10315628.html
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  | url=http://www.independent.co.uk/life-style/health-and-families/health-news/man-who-had-worlds-first-penis-transplant-to-become-a-father-10315628.html
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  |title=Man who had world's first penis transplant to become a father
−
  | title=Man who had world's first penis transplant to become a father
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  |publisher=The Independent
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  | publisher=The Independent
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  |quote=
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| work=
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  |date=2015-06-12
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  | quote=
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  |accessdate=2015-07-15
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  | date=2015-06-12
 
−
  | accessdate=2015-07-15
 
 
}}</ref> and phalloplasties<ref>{{REFnews
 
}}</ref> and phalloplasties<ref>{{REFnews
−
  | last=Ho
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  |last=Ho
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  | first=Vivian
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  |first=Vivian
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| coauthors=
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  |url=http://www.sfgate.com/health/article/Man-may-be-1st-to-father-child-with-reconstructed-5416853.php
−
  | url=http://www.sfgate.com/health/article/Man-may-be-1st-to-father-child-with-reconstructed-5416853.php
+
  |title=Man may be 1st to father child with reconstructed penis
−
  | title=Man may be 1st to father child with reconstructed penis
+
  |publisher=SFGate
−
  | publisher=SFGate
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  |quote=
−
| work=
+
  |date=2014-04-22
−
  | quote=
+
  |accessdate=2015-07-15
−
  | date=2014-04-22
+
}}</ref>. However, regenerative medicine has not yet been applied to those who have been [[circumcised]], but no longer wish to be.
−
  | accessdate=2015-07-15
 
−
}}</ref>. However, regenerative medicine has not yet been applied to those who have been circumcised and no longer wish to be.
 
  
−
Foregen was founded by Mr. [[Vincenzo Aiello]] to promote and arrange a clinical trial that would use regenerative techniques to regrow the tissue removed at circumcision. After dismissing many unsatisfactory proposals from research institutions, Foregen decided to conduct its own research and clinical trials. Foregen has applied regenerative techniques to animal foreskins and will continue research on adult human foreskins.
+
For more information on the science behind Foregen, read: [http://www.foregen.org/science_of_regeneration The science of regeneration]
  
 +
==Goals==
 
Foregen’s tasks are:
 
Foregen’s tasks are:
  
 
* To experiment with animal tissue to obtain a viable method of foreskin regeneration
 
* To experiment with animal tissue to obtain a viable method of foreskin regeneration
−
* To apply the expirience from animal experiments to regenerate human foreskins
+
* To apply the experience from animal experiments to regenerate human foreskins
 
* To advance onto clinical trials once Foregen proves that regenerating human foreskin is possible
 
* To advance onto clinical trials once Foregen proves that regenerating human foreskin is possible
  
−
Foregen™ was created in 2010 thanks to donor funds. Foregen operates in the United States and Europe. Its head office is in Rome, Italy, where it is a registered charity (Reg. No. 6482, Serie 1T, 2010). See original founding documents here. Foregen is also tax-exempt under section 501(c)(3) of the internal revenue code and is headed by a board of charitable directors with participants and donors across both continents and beyond.
+
==Foregen is a charity==
  
−
For more information on the science behind Foregen, read: [http://www.foregen.org/science_of_regeneration The science of regeneration]
+
Foregen™ was created in 2010 thanks to donor funds. Foregen operates in the [[United States]] and Europe. Its head office is in Rome, Italy, where it is a registered charity (Reg. No. 6482, Serie 1T, 2010). See original founding documents here. Foregen is also tax-exempt under section 501(c)(3) of the Internal Revenue Code and is headed by a board of charitable directors with participants and donors across both continents and beyond.
  
−
== Website ==
+
Foreget announced on 19 December 2021 that its cummulative donations had exceeded $1 million.
−
* http://www.foregen.org/
 
  
−
Message from Foregen's president, [[Vincenzo Aiello]].
+
== Videos ==
−
<youtube>2ywXUcSW4kQ</youtube><br><br>
+
=== Message from Foregen's president, [[Vincenzo Aiello]] ===
 +
<youtube>2ywXUcSW4kQ</youtube>
  
 +
=== HUFO - The Missing Piece ===
 
<youtube>l0o411Lu8Yg</youtube>
 
<youtube>l0o411Lu8Yg</youtube>
 +
 +
===Foregen and the Science of Regeneration===
 +
<youtube>JTOoc8ToSjc</youtube>
 +
 +
===Sheep Trials Part 1: Preparing the Sheep and Attaching ECMs===
 +
<youtube>lI8TKqkF4Hw</youtube>
 +
 +
===Consultation with Dr. Dan mon O'Dey===
 +
<youtube>5uxBJHiscJ8</youtube>
 +
 +
===Vincenzo Aiello announces success of sheep trials===
 +
<youtube>SIsIg1gm5N8</youtube>
 +
 +
===Foreskin sensation===
 +
<youtube>_t7uduP9egk</youtube>
 +
 +
==Progress reports==
 +
 +
Forgen released the results of a survey on 9 January 2023 which reported that 21 percent of American [[circumcised]] men (more than 18 million) would consider undergoing a procedure to regenerate their [[foreskin]].‍<ref>{{REFweb
 +
|url=https://www.foregen.org/commentarium-articles/5-million-men-more-than-triple-that-over-18-million-american-men-would-consider-regenerating-their-foreskin
 +
|title=5 Million Men? More Than Triple That: Over 18 Million American Men Would Consider Regenerating Their Foreskin.
 +
|last=Serody
 +
|first=Matthew R.
 +
|init=
 +
|publisher=Foregen
 +
|date=2023-01-09
 +
|accessdate=2023-01-11
 +
}}</ref>
 +
 +
As of March 2024, Foregen has not yet regenerated a [[foreskin]].
  
 
== Social media ==
 
== Social media ==
−
* [https://www.youtube.com/channel/UCUPHstb4Zzc-e1lbJVrT5HA Youtube Channel]
+
* [https://www.youtube.com/channel/UCUPHstb4Zzc-e1lbJVrT5HA Youtube channel]
−
* [https://www.facebook.com/foregen Facebook page]
+
* {{URL-FBpage|foregen|2021-12-20}}
−
* [https://twitter.com/foregen Twitter]
+
* {{URLtwitter|foregen|2021-12-20}}
  
 
== Foregen in the media ==
 
== Foregen in the media ==
−
* [http://motherboard.vice.com/read/regrowing-foreskins-like-salamander-arms Vice: How One Company Aims to Help Circumcised Men Grow Their Foreskin Back]
+
* {{REFnews
−
* [http://www.dailymail.co.uk/health/article-2958422/Circumcised-men-soon-able-REGROW-foreskin-New-technique-help-increasing-number-men-angry-given-procedure.html Daily Mail: Circumcised men may soon be able to REGROW their foreskin: New technique could help increasing number of men angry they were given the procedure]
+
|title=How One Company Aims to Help Circumcised Men Grow Their Foreskin Back
−
* [http://www.mirror.co.uk/news/technology-science/science/circumcised-foregen-wants-regrow-your-5185843 Mirror: Circumcised? Foregen wants to regrow your foreskin and restore sexual pleasure]
+
|url=http://motherboard.vice.com/read/regrowing-foreskins-like-salamander-arms
−
* [http://www.queerty.com/circumcised-men-may-soon-be-able-to-regrow-their-foreskin-thanks-to-new-miracle-therapy-20150219 Querty: Circumcised Men May Soon Be Able To Regrow Their Foreskin Thanks To New Miracle Therapy]
+
|last=Millican
 +
|first=Arika
 +
|coauthors=
 +
|publisher=Vice
 +
|website=
 +
|date=2015-02-17
 +
|accessdate=2020-02-09
 +
|quote=
 +
}}
 +
* {{REFnews
 +
|title=Circumcised men may soon be able to REGROW their foreskin: New technique could help increasing number of men angry they were given the procedure
 +
|url=http://www.dailymail.co.uk/health/article-2958422/Circumcised-men-soon-able-REGROW-foreskin-New-technique-help-increasing-number-men-angry-given-procedure.html
 +
|last=Davies
 +
|first=Madlen
 +
|coauthors=
 +
|publisher=The Daily Mail
 +
|website=
 +
|date=2015-02-20
 +
|accessdate=2020-02-09
 +
|quote=
 +
}}
 +
* {{REFnews
 +
|title=Circumcised? Foregen wants to regrow your foreskin and restore sexual pleasure
 +
|url=http://www.mirror.co.uk/news/technology-science/science/circumcised-foregen-wants-regrow-your-5185843
 +
|last=Solon
 +
|first=Oliva
 +
|coauthors=
 +
|publisher=Mirror
 +
|website=
 +
|date=2015-02-19
 +
|accessdate=2020-02-09
 +
|quote=
 +
}}
 +
* [http://www.queerty.com/circumcised-men-may-soon-be-able-to-regrow-their-foreskin-thanks-to-new-miracle-therapy-20150219 Queerty: Circumcised Men May Soon Be Able To Regrow Their Foreskin Thanks To New Miracle Therapy]
 
* [http://www.queerty.com/queerty-readers-respond-to-news-that-men-will-soon-be-able-to-regrow-their-foreskin-20150220 Queerty: Queerty Readers Respond To News That Men Will Soon Be Able To Regrow Their Foreskin]
 
* [http://www.queerty.com/queerty-readers-respond-to-news-that-men-will-soon-be-able-to-regrow-their-foreskin-20150220 Queerty: Queerty Readers Respond To News That Men Will Soon Be Able To Regrow Their Foreskin]
 
* [http://www.thegailygrind.com/2015/02/19/circumcised-men-may-soon-able-regrow-foreskin-new-therapy/ The gaily grind: Circumcised Men May Soon Be Able To Regrow Their Foreskin With New Therapy]
 
* [http://www.thegailygrind.com/2015/02/19/circumcised-men-may-soon-able-regrow-foreskin-new-therapy/ The gaily grind: Circumcised Men May Soon Be Able To Regrow Their Foreskin With New Therapy]
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{{SEEALSO}}
 
{{SEEALSO}}
 +
* [[Foreskin]]
 +
* [[Penis]]
 +
* [[Restoration]]
 +
* [[Ridged band]]
 +
* [[Psychological issues of male circumcision]]
 +
* [[Basics of foreskin restoration]]
 +
* [[Surgical foreskin restoration]]
 +
* [[Literature about foreskin restoration]]
 +
 +
{{LINKS}}
 +
* {{URLwebsite|http://www.foregen.org|2019-09-16}}
 
* [https://en.wikipedia.org/wiki/Genital_regeneration Wikipedia: Genital regeneration]
 
* [https://en.wikipedia.org/wiki/Genital_regeneration Wikipedia: Genital regeneration]
  
 
{{REF}}
 
{{REF}}
  
−
[[Category:Under construction]]
+
[[Category:Foregen]]
 
[[Category:Foreskin restoration]]
 
[[Category:Foreskin restoration]]
  
 
[[Category:From IntactWiki]]
 
[[Category:From IntactWiki]]

Latest revision as of 07:41, 1 July 2024

Foregen logo.png

Foregen is a registered Italian charity. Foregen was founded by Sig. Vincenzo Aiello of Italy to promote and arrange a clinical trial that would use regenerative techniques to regrow the tissue removed at circumcision. Foregen's goal is to heal the physical loss of functional tissue that is inherent to circumcision. Foregen's principal office is at Via Campi Flegrei 59, 00141 Rome, Italy.

History

After dismissing many unsatisfactory proposals from research institutions, Foregen decided to conduct its own research and clinical trials. Foregen has applied regenerative techniques to animal foreskins and will continue research on adult human foreskins.

Foregen announced in 2018 that it had completed a decellularized extracellular matrix–based biomaterial scaffold, which is to be used in foreskin regeneration.[1]

Foregen announced in December 2021 that it is hoped that clinical trials would commence in April 2023.[2]

Regenerative medicine

Regenerative medical techniques now offer a greater possibility than ever to regrow human tissue, especially dermal tissue, lost in prior trauma. Regenerative medicine has been used to recreate vaginas of women with some congenital conditions[3]. Experiments have been performed to regenerate the penis of rabbits.[4] [5][6] Also progress has been made in penile transplants[7] [8] and phalloplasties[9]. However, regenerative medicine has not yet been applied to those who have been circumcised, but no longer wish to be.

For more information on the science behind Foregen, read: The science of regeneration

Goals

Foregen’s tasks are:

  • To experiment with animal tissue to obtain a viable method of foreskin regeneration
  • To apply the experience from animal experiments to regenerate human foreskins
  • To advance onto clinical trials once Foregen proves that regenerating human foreskin is possible

Foregen is a charity

Foregen™ was created in 2010 thanks to donor funds. Foregen operates in the United States and Europe. Its head office is in Rome, Italy, where it is a registered charity (Reg. No. 6482, Serie 1T, 2010). See original founding documents here. Foregen is also tax-exempt under section 501(c)(3) of the Internal Revenue Code and is headed by a board of charitable directors with participants and donors across both continents and beyond.

Foreget announced on 19 December 2021 that its cummulative donations had exceeded $1 million.

Videos

Message from Foregen's president, Vincenzo Aiello

HUFO - The Missing Piece

Foregen and the Science of Regeneration

Sheep Trials Part 1: Preparing the Sheep and Attaching ECMs

Consultation with Dr. Dan mon O'Dey

Vincenzo Aiello announces success of sheep trials

Foreskin sensation

Progress reports

Forgen released the results of a survey on 9 January 2023 which reported that 21 percent of American circumcised men (more than 18 million) would consider undergoing a procedure to regenerate their foreskin.‍[10]

As of March 2024, Foregen has not yet regenerated a foreskin.

Social media

Foregen in the media

See also

External links

References

  1. ↑ REFjournal Purpura V, Bondioli E, Cunningham EC, et al. The development of a decellularized extracellular matrix–based biomaterial scaffold derived from human foreskin for the purpose of foreskin reconstruction in circumcised males. J Tissue Eng. 22 December 2018; PMID. PMC. DOI. Retrieved 9 February 2020.
  2. ↑ REFweb (December 2021). Human Clinical Trials Application Form. Retrieved 20 December 2021.
  3. ↑ REFnews Richardson, Karen (10 April 2014)."Laboratory-Grown Vaginas Implanted in Patients, Scientists Report", Wake Forest Baptist Medical Center. Retrieved 15 July 2015.
  4. ↑ REFnews Geggel, Laura (9 October 2014)."Scientists developing lab-grown penis for transplant", LiveScience, CBS News. Retrieved 15 July 2015.
  5. ↑ REFnews "Engineered Penile Erectile Tissue", Wake Forest School of Medicine. Retrieved 15 July 2015.
  6. ↑ REFnews Mohammadi, Dara (4 October 2014)."The lab-grown penis: approaching a medical milestone", The Guardian. Retrieved 15 July 2015.
  7. ↑ REFnews Smith, David (13 March 2015)."Man gets world's first successful penis transplant after botched circumcision", The Guardian. Retrieved 15 July 2015.
  8. ↑ REFnews Feltman, Rachel (12 June 2015)."Man who had world's first penis transplant to become a father", The Independent. Retrieved 15 July 2015.
  9. ↑ REFnews Ho, Vivian (22 April 2014)."Man may be 1st to father child with reconstructed penis", SFGate. Retrieved 15 July 2015.
  10. ↑ REFweb Serody, Matthew R. (9 January 2023). 5 Million Men? More Than Triple That: Over 18 Million American Men Would Consider Regenerating Their Foreskin., Foregen. Retrieved 11 January 2023.
Retrieved from "https://en.intactiwiki.org/w/index.php?title=Foregen&oldid=38749"