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==Description==
When boys are born, the preputial sac is sealed shut by a [[synechia]] called the ''balanopreputial lamina'', ,<ref name="deibart1933">{{REFjournal |last=Deibart |init=GA |title=The separation of the prepuce in the human penis |journal=Anat Rec |date=1933 |volume=57 |issue= |pages=387-99 |url=http://www.cirp.org/library/anatomy/deibert/ |quote= |DOI=https://doi.org/10.1002/ar.1090570409 |accessdate=2023-05-23}}</ref> so it cannot be infected. The preputial sac will remain closed for a variable number of years.
The preputial sac is lined with [[mucosa]] as is appropriate for an internal organ where moisture is present.<ref name="cold-taylor1999">{{ColdCJ TaylorJR 1999}}</ref> Urine and other sources of moisture are not harmful to it.